LINE Drive: Retrotransposition and Genome Instability

The LINE-1 (L1) retrotransposon, the most important human mobile element, shapes the genome in many ways. Now two groups provide evidence that L1 retrotransposition is associated with large genomic deletions and inversions in transformed cells. If these events occur at a similar frequency in vivo, t...

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Veröffentlicht in:	Cell 2002-08, Vol.110 (3), p.277-280
Hauptverfasser:	Kazazian, Haig H., Goodier, John L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Capsid - genetics Capsid Proteins Evolution, Molecular Gene Deletion Genome, Human Glycoproteins - genetics Humans Long Interspersed Nucleotide Elements - genetics Mice Mutagenesis, Site-Directed - genetics Mutation - genetics Polymorphism, Genetic - genetics Retroelements - genetics
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The LINE-1 (L1) retrotransposon, the most important human mobile element, shapes the genome in many ways. Now two groups provide evidence that L1 retrotransposition is associated with large genomic deletions and inversions in transformed cells. If these events occur at a similar frequency in vivo, they have had a substantial effect on human genome evolution.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/S0092-8674(02)00868-1