NMDA receptor subunit expression following early postnatal exposure to ethanol

Changes in NMDA receptor function following early postnatal exposure to ethanol may be related to the expression of NMDA receptor subunits. Following early postnatal exposure to ethanol, the expression of NMDA receptor subunits was examined. In cortex from ethanol-exposed rat pups at postnatal day 2...

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Veröffentlicht in:	Brain research. Developmental brain research 2002-12, Vol.139 (2), p.295-299
Hauptverfasser:	Nixon, Kimberly, Hughes, Peter D., Amsel, Abram, Leslie, Steven W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol-Induced Disorders, Nervous System - metabolism Alcohol-Induced Disorders, Nervous System - physiopathology Animals Animals, Newborn Brain - drug effects Brain - growth & development Brain - metabolism Cerebral Cortex - drug effects Cerebral Cortex - growth & development Cerebral Cortex - metabolism Cortex Disease Models, Animal Ethanol Ethanol - pharmacology Female Fetal Alcohol Spectrum Disorders - metabolism Fetal Alcohol Spectrum Disorders - physiopathology Hippocampus Hippocampus - drug effects Hippocampus - growth & development Hippocampus - metabolism Immunohistochemistry Male Neurons - drug effects Neurons - metabolism NMDA Postnatal Pregnancy Prenatal Exposure Delayed Effects Rat Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - metabolism
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Zusammenfassung:	Changes in NMDA receptor function following early postnatal exposure to ethanol may be related to the expression of NMDA receptor subunits. Following early postnatal exposure to ethanol, the expression of NMDA receptor subunits was examined. In cortex from ethanol-exposed rat pups at postnatal day 21, NR2A was significantly increased. There was no change in NR2B, thus suggesting that ethanol exposure during the third-trimester equivalent produces distinct effects on the NMDA receptor.
ISSN:	0165-3806
DOI:	10.1016/S0165-3806(02)00515-1