Increased insular connectivity with emotional regions in primary insomnia patients: a resting-state fMRI study

Objective To explore the abnormal connectivity patterns between the insular and the voxels of the brain in primary insomnia (PI) with insular-based functional connectivity (FC). Methods With the resting-state fMRI data acquired from 57 PI patients and 46 healthy controls, a two-sample t test was performed on individual FC correlation maps from two groups. The person correlation analysis was used to evaluate the relationship between the abnormal FC and clinical features. Results PI patients show enhanced connectivity between the left insula with the right anterior cingulate cortex ( p