Polysorbate 80 and polymyxin B inhibit Stenotrophomonas maltophilia biofilm

Abstract Stenotrophomonas maltophilia is an opportunistic multiple-drug-resistant human pathogen that forms biofilms on implanted medical devices. We examined the potential inhibitory activity of polysorbate 80 and polymyxin B against S. maltophilia . A combination of subMIC polymyxin B and polysorb...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 2017-02, Vol.87 (2), p.154-156
Hauptverfasser:	Malinowski, Adam M, McClarty, Bryan M, Robinson, Carolyn, Spear, William, Sanchez, Maria, Sparkes, Timothy C, Brooke, Joanna S
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Biofilm Biofilms - drug effects Drug Interactions Humans Infectious Disease Internal Medicine Microbial Sensitivity Tests Polymyxin B Polymyxin B - pharmacology Polysorbate Polysorbates - pharmacology Stenotrophomonas Stenotrophomonas maltophilia Stenotrophomonas maltophilia - drug effects Stenotrophomonas maltophilia - physiology subMIC Surface-Active Agents - pharmacology Surfactant
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Zusammenfassung:	Abstract Stenotrophomonas maltophilia is an opportunistic multiple-drug-resistant human pathogen that forms biofilms on implanted medical devices. We examined the potential inhibitory activity of polysorbate 80 and polymyxin B against S. maltophilia . A combination of subMIC polymyxin B and polysorbate 80 was the most effective inhibitor of growth and biofilm formation.
ISSN:	0732-8893 1879-0070
DOI:	10.1016/j.diagmicrobio.2016.11.008