Emergence of plasmid-mediated colistin resistance ( mcr-1 ) and New Delhi Metallo β -lactamase (NDM-1) genes in extensively drug resistant Escherichia coli isolated from a patient in Thailand

Abstract We reported a case of E.coli with colistin resistance and an extensively drug resistant phenotype. Molecular analysis revealed that the isolate carried mcr-1 and multiple β -lactamase genes including, blaNDM1 , blaCTX-M-15 , blaTEM1 , and blaCMY-2 . This is the first report of a clinical mc...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 2017-02, Vol.87 (2), p.157-159
Hauptverfasser:	Paveenkittiporn, Wantana, Kerdsin, Anusak, Chokngam, Sukanya, Bunthi, Charatdao, Sangkitporn, Somchai, Gregory, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology beta-Lactamases - genetics Colistin - pharmacology Colistin resistance Drug Resistance, Multiple, Bacterial Escherichia coli Escherichia coli - drug effects Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli - isolation & purification Escherichia coli Infections - microbiology Genes, Bacterial Humans Infectious Disease Internal Medicine Male mcr-1 Microbial Sensitivity Tests Middle Aged Multiplex Polymerase Chain Reaction Plasmids - analysis Sequence Analysis, DNA Thailand XDR E.coli
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Zusammenfassung:	Abstract We reported a case of E.coli with colistin resistance and an extensively drug resistant phenotype. Molecular analysis revealed that the isolate carried mcr-1 and multiple β -lactamase genes including, blaNDM1 , blaCTX-M-15 , blaTEM1 , and blaCMY-2 . This is the first report of a clinical mcr-1 isolate in Thailand highlighting the urgent need for a comprehensive antimicrobial resistance containment strategy to prevent further spread.
ISSN:	0732-8893 1879-0070
DOI:	10.1016/j.diagmicrobio.2016.11.005