The effects of hydroporation on melasma with anti‐aging cocktail

Summary Background Jet‐M is a device for epidermal peeling and is used to deliver substances by spraying air and microdroplets. Previously, a case was treated with a mixed solution of copper‐GHK, oligo‐hyaluronic acid, Rhodiola extract, tranexamic acid, and β‐glucan. The results showed significant improvement of aged skin. Aims This study was conducted to evaluate the effects of hydroporation on melasma with the formulation in a small group of volunteers. Methods Clinical effects were evaluated by both subjective and objective methods including melanin index (MI) and erythema index (EI) measurement. Results Clinically, pigmentation and erythema were relieved and also both MI and EI decreased. Histopathologic observation revealed that type IV collagen and procollagen were increased in the upper dermis. Furthermore, the number of p63‐positive cells is increased along the basement membrane. These results all suggest that hydroporation with GHR formulation induced anti‐aging effects by reconstruction of extracellular matrix. Conclusion These findings suggest that the treatment may have depigmenting effects and erythema decreasing effects by enhancing the microenvironment of the skin.