Antigen-specific secretion of IFNγ and CXCL10 in whole blood assay detects Mycobacterium leprae infection but does not discriminate asymptomatic infection from symptomatic leprosy

Abstract To advance toward a whole blood assay/WBA-based test capable of facilitating the diagnosis of paucibacillary/PB leprosy, we evaluated a prototype in-tube WBA using combinations of M. leprae antigens. Blood was collected from newly diagnosed untreated PB (n = 38), multibacillary/MB (n = 30),...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 2017-04, Vol.87 (4), p.328-334
Hauptverfasser:	Hungria, Emerith Mayra, Freitas, Aline Araújo, de Andrade Pontes, Maria Araci, de Sá Gonçalves, Heitor, de Sousa, Ana Lúcia Osório Maroccolo, Costa, Maurício Barcelos, de Oliveira Rodrigues Castilho, Mirian Lane, Duthie, Malcolm S, de Araújo Stefani, Mariane Martins
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antibodies, Bacterial - immunology Antigens, Bacterial - immunology Asymptomatic Infections - epidemiology Biological Assay - methods Brazil Cell-mediated immunity Chemokine CXCL10 - immunology CXCL10 Diagnosis Female Humans IFNγ Infectious Disease Interferon-gamma - immunology Internal Medicine Leprosy Leprosy, Paucibacillary - blood Leprosy, Paucibacillary - diagnosis Leprosy, Paucibacillary - immunology Leprosy, Paucibacillary - microbiology Male Middle Aged Mycobacterium leprae - immunology Mycobacterium tuberculosis - immunology Recombinant Proteins - immunology Whole blood assay Young Adult
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