Synthesis, Spectral Characterization, Crystal structure, Cytotoxicity and Apoptosis − inducing Activity of two derivatives of 2-hydroxy-1,4-naphthaquinone
Highlights • Ultrasound assisted synthesis of lawsone derivatives with anticancer properties. • Single crystal X-ray analysis of 5H–Benzo[a]phenoxazin–5–one. • Find the ADMET properties. • In silico molecular docking studies. • Cytotoxic and preliminary apoptosis inducing activity of two derivatives...
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| Veröffentlicht in: | Photodiagnosis and photodynamic therapy 2017-03, Vol.17, p.250-259 |
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| container_title | Photodiagnosis and photodynamic therapy |
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| creator | P.R., Kavitha Rani Fernandez, Annette Laila, Shiny P B., Arunkumar C.S., Sreelakshmi V.S., Vishnu |
| description | Highlights • Ultrasound assisted synthesis of lawsone derivatives with anticancer properties. • Single crystal X-ray analysis of 5H–Benzo[a]phenoxazin–5–one. • Find the ADMET properties. • In silico molecular docking studies. • Cytotoxic and preliminary apoptosis inducing activity of two derivatives |
| doi_str_mv | 10.1016/j.pdpdt.2017.01.180 |
| format | Article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-5bad76f079f0b2948194b4703c61d9ce2baadd2917d42c559642873ec3115e163</citedby><cites>FETCH-LOGICAL-c414t-5bad76f079f0b2948194b4703c61d9ce2baadd2917d42c559642873ec3115e163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pdpdt.2017.01.180$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28122250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>P.R., Kavitha Rani</creatorcontrib><creatorcontrib>Fernandez, Annette</creatorcontrib><creatorcontrib>Laila, Shiny P</creatorcontrib><creatorcontrib>B., Arunkumar</creatorcontrib><creatorcontrib>C.S., Sreelakshmi</creatorcontrib><creatorcontrib>V.S., Vishnu</creatorcontrib><title>Synthesis, Spectral Characterization, Crystal structure, Cytotoxicity and Apoptosis − inducing Activity of two derivatives of 2-hydroxy-1,4-naphthaquinone</title><title>Photodiagnosis and photodynamic therapy</title><addtitle>Photodiagnosis Photodyn Ther</addtitle><description>Highlights • Ultrasound assisted synthesis of lawsone derivatives with anticancer properties. • Single crystal X-ray analysis of 5H–Benzo[a]phenoxazin–5–one. • Find the ADMET properties. • In silico molecular docking studies. • Cytotoxic and preliminary apoptosis inducing activity of two derivatives</description><subject>Apoptosis - drug effects</subject><subject>Benzoxazines - chemistry</subject><subject>Benzoxazines - pharmacology</subject><subject>Cell Death - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Crystallography, X-Ray</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lawsone</subject><subject>Molecular Docking Simulation</subject><subject>Naphthoquinones - chemistry</subject><subject>Naphthoquinones - pharmacology</subject><subject>Orthoaminophenol and in silico molecular docking studies</subject><subject>Structure-Activity Relationship</subject><subject>Ultrasound irradiation</subject><issn>1572-1000</issn><issn>1873-1597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUj2P1DAQjRCIOw5-ARJySbEJHue7AGm1ggPpJIoFic5y7FniJWvnbGe58Auor-bX8Utw2IOChmLk0fi9N5p5kyRPgWZAoXqxz0Y1qpAxCnVGIYOG3kvOoanzFMq2vh_zsmYpUErPkkfe7ynNi5YWD5Mz1gBjrKTnyY_tbEKPXvsV2Y4ogxMD2fTCCRnQ6W8iaGtWZONmH-KPD26SYXIYS3Owwd5oqcNMhFFkPdox2KhEfn6_JdqoSWrzmaxl0McFY3ckfLVERdljlD2iX0os7Wfl7M2cwqpIjRj70IvrSRtr8HHyYCcGj0_u3ovk45vXHzZv06v3l-8266tUFlCEtOyEqqsdrdsd7VhbNNAWXVHTXFagWomsE0Ip1kKtCibLsq0KFreEMgcoEar8Inl-0h2dvZ7QB37QXuIwCIN28hyairGmZPUCzU9Q6az3Dnd8dPog3MyB8sUWvue_beGLLZxCJNPIenbXYOoOqP5y_vgQAS9PAIxjHjU67qVGI1FpF03hyur_NHj1D18O2mgphi84o9_byZm4QQ7cM075drmM5TDi8DHKT_kv9d-31w</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>P.R., Kavitha Rani</creator><creator>Fernandez, Annette</creator><creator>Laila, Shiny P</creator><creator>B., Arunkumar</creator><creator>C.S., Sreelakshmi</creator><creator>V.S., Vishnu</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170301</creationdate><title>Synthesis, Spectral Characterization, Crystal structure, Cytotoxicity and Apoptosis − inducing Activity of two derivatives of 2-hydroxy-1,4-naphthaquinone</title><author>P.R., Kavitha Rani ; Fernandez, Annette ; Laila, Shiny P ; B., Arunkumar ; C.S., Sreelakshmi ; V.S., Vishnu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-5bad76f079f0b2948194b4703c61d9ce2baadd2917d42c559642873ec3115e163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Apoptosis - drug effects</topic><topic>Benzoxazines - chemistry</topic><topic>Benzoxazines - pharmacology</topic><topic>Cell Death - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Crystallography, X-Ray</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lawsone</topic><topic>Molecular Docking Simulation</topic><topic>Naphthoquinones - chemistry</topic><topic>Naphthoquinones - pharmacology</topic><topic>Orthoaminophenol and in silico molecular docking studies</topic><topic>Structure-Activity Relationship</topic><topic>Ultrasound irradiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>P.R., Kavitha Rani</creatorcontrib><creatorcontrib>Fernandez, Annette</creatorcontrib><creatorcontrib>Laila, Shiny P</creatorcontrib><creatorcontrib>B., Arunkumar</creatorcontrib><creatorcontrib>C.S., Sreelakshmi</creatorcontrib><creatorcontrib>V.S., Vishnu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Photodiagnosis and photodynamic therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>P.R., Kavitha Rani</au><au>Fernandez, Annette</au><au>Laila, Shiny P</au><au>B., Arunkumar</au><au>C.S., Sreelakshmi</au><au>V.S., Vishnu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, Spectral Characterization, Crystal structure, Cytotoxicity and Apoptosis − inducing Activity of two derivatives of 2-hydroxy-1,4-naphthaquinone</atitle><jtitle>Photodiagnosis and photodynamic therapy</jtitle><addtitle>Photodiagnosis Photodyn Ther</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>17</volume><spage>250</spage><epage>259</epage><pages>250-259</pages><issn>1572-1000</issn><eissn>1873-1597</eissn><abstract>Highlights • Ultrasound assisted synthesis of lawsone derivatives with anticancer properties. • Single crystal X-ray analysis of 5H–Benzo[a]phenoxazin–5–one. • Find the ADMET properties. • In silico molecular docking studies. • Cytotoxic and preliminary apoptosis inducing activity of two derivatives</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28122250</pmid><doi>10.1016/j.pdpdt.2017.01.180</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1572-1000 |
| ispartof | Photodiagnosis and photodynamic therapy, 2017-03, Vol.17, p.250-259 |
| issn | 1572-1000 1873-1597 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Apoptosis - drug effects Benzoxazines - chemistry Benzoxazines - pharmacology Cell Death - drug effects Cell Line, Tumor Cell Survival - drug effects Crystallography, X-Ray Hematology, Oncology and Palliative Medicine Humans Internal Medicine Lawsone Molecular Docking Simulation Naphthoquinones - chemistry Naphthoquinones - pharmacology Orthoaminophenol and in silico molecular docking studies Structure-Activity Relationship Ultrasound irradiation |
| title | Synthesis, Spectral Characterization, Crystal structure, Cytotoxicity and Apoptosis − inducing Activity of two derivatives of 2-hydroxy-1,4-naphthaquinone |
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