Synthesis, Spectral Characterization, Crystal structure, Cytotoxicity and Apoptosis − inducing Activity of two derivatives of 2-hydroxy-1,4-naphthaquinone

Synthesis, Spectral Characterization, Crystal structure, Cytotoxicity and Apoptosis − inducing Activity of two derivatives of 2-hydroxy-1,4-naphthaquinone

Highlights • Ultrasound assisted synthesis of lawsone derivatives with anticancer properties. • Single crystal X-ray analysis of 5H–Benzo[a]phenoxazin–5–one. • Find the ADMET properties. • In silico molecular docking studies. • Cytotoxic and preliminary apoptosis inducing activity of two derivatives...

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Veröffentlicht in:Photodiagnosis and photodynamic therapy 2017-03, Vol.17, p.250-259
Hauptverfasser: P.R., Kavitha Rani, Fernandez, Annette, Laila, Shiny P, B., Arunkumar, C.S., Sreelakshmi, V.S., Vishnu
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis - drug effects
Benzoxazines - chemistry
Benzoxazines - pharmacology
Cell Death - drug effects
Cell Line, Tumor
Cell Survival - drug effects
Crystallography, X-Ray
Hematology, Oncology and Palliative Medicine
Humans
Internal Medicine
Lawsone
Molecular Docking Simulation
Naphthoquinones - chemistry
Naphthoquinones - pharmacology
Orthoaminophenol and in silico molecular docking studies
Structure-Activity Relationship
Ultrasound irradiation
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Zusammenfassung:Highlights • Ultrasound assisted synthesis of lawsone derivatives with anticancer properties. • Single crystal X-ray analysis of 5H–Benzo[a]phenoxazin–5–one. • Find the ADMET properties. • In silico molecular docking studies. • Cytotoxic and preliminary apoptosis inducing activity of two derivatives
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2017.01.180