Activity of a melimine derived peptide Mel4 against Stenotrophomonas, Delftia, Elizabethkingia, Burkholderia and biocompatibility as a contact lens coating
Highlights • Mel4 contact lens coating retain high activity against Delftia, Stenotrophomonas, Elizabethkingia, Burkholderia. • Mel4 coated antimicrobial contact lenses are biocompatible during 22 days rabbit lens wear. • These lenses did not show increased redness or corneal staining during 1 week...
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| Veröffentlicht in: | Contact lens & anterior eye 2017-06, Vol.40 (3), p.175-183 |
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| container_title | Contact lens & anterior eye |
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| creator | Dutta, Debarun Zhao, Timothy Cheah, Kai Bing Holmlund, Larke Willcox, Mark D.P |
| description | Highlights • Mel4 contact lens coating retain high activity against Delftia, Stenotrophomonas, Elizabethkingia, Burkholderia. • Mel4 coated antimicrobial contact lenses are biocompatible during 22 days rabbit lens wear. • These lenses did not show increased redness or corneal staining during 1 week daily wear for humans. |
| doi_str_mv | 10.1016/j.clae.2017.01.002 |
| format | Article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-2b89895b7e1df45191d9a04aa03f653e9c5289770750760534a69dbb721f7d383</citedby><cites>FETCH-LOGICAL-c455t-2b89895b7e1df45191d9a04aa03f653e9c5289770750760534a69dbb721f7d383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1367048416301163$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28118996$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dutta, Debarun</creatorcontrib><creatorcontrib>Zhao, Timothy</creatorcontrib><creatorcontrib>Cheah, Kai Bing</creatorcontrib><creatorcontrib>Holmlund, Larke</creatorcontrib><creatorcontrib>Willcox, Mark D.P</creatorcontrib><title>Activity of a melimine derived peptide Mel4 against Stenotrophomonas, Delftia, Elizabethkingia, Burkholderia and biocompatibility as a contact lens coating</title><title>Contact lens & anterior eye</title><addtitle>Cont Lens Anterior Eye</addtitle><description>Highlights • Mel4 contact lens coating retain high activity against Delftia, Stenotrophomonas, Elizabethkingia, Burkholderia. • Mel4 coated antimicrobial contact lenses are biocompatible during 22 days rabbit lens wear. • These lenses did not show increased redness or corneal staining during 1 week daily wear for humans.</description><subject>Animals</subject><subject>Antimicrobial</subject><subject>Antimicrobial Cationic Peptides - pharmacology</subject><subject>Bacterial Adhesion - drug effects</subject><subject>Burkholderia - drug effects</subject><subject>Burkholderia - isolation & purification</subject><subject>Burkholderia Infections - microbiology</subject><subject>Burkholderia Infections - prevention & control</subject><subject>Coated Materials, Biocompatible - chemistry</subject><subject>Contact lens</subject><subject>Contact Lenses - microbiology</subject><subject>Delftia</subject><subject>Disease Models, Animal</subject><subject>Equipment Contamination - prevention & control</subject><subject>Eye Infections, Bacterial - microbiology</subject><subject>Eye Infections, Bacterial - prevention & control</subject><subject>Female</subject><subject>Gram-Negative Bacterial Infections - microbiology</subject><subject>Gram-Negative Bacterial Infections - prevention & control</subject><subject>Materials Testing - methods</subject><subject>Mel4</subject><subject>Melimine</subject><subject>Microbial Sensitivity Tests - methods</subject><subject>Ophthalmology</subject><subject>Prospective Studies</subject><subject>Rabbits</subject><subject>Stenotrophomonas</subject><subject>Stenotrophomonas - drug effects</subject><subject>Stenotrophomonas - isolation & purification</subject><issn>1367-0484</issn><issn>1476-5411</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kstu1DAUhiMEoqXwAiyQlyw6g09ujiWEVEq5SEUsCmvLsU9mPOPYqe2MNLwKL4ujKSxYsPH1__8j-ztF8RLoGii0b3ZrZSWuSwpsTWFNafmoOIeataumBnic11XLVrTu6rPiWYw7mk2c06fFWdkBdJy358WvK5XMwaQj8QORZERrRuOQaAzmgJpMOCWjkXxFWxO5kcbFRO4SOp-Cn7Z-9E7GS_IB7ZCMvCQ31vyUPabt3rjNcvB-Dvutt0ueJNJp0huv_DjJZHpjl8Iy5sLKuyRVIhZdzJt86zbPiyeDtBFfPMwXxY-PN9-vP69uv336cn11u1J106RV2Xe8403PEPRQN8BBc0lrKWk1tE2FXDVlxxmjrKGspU1Vy5brvmclDExXXXVRvD7lTsHfzxiTGE1UaK106OcooGuha6BidZaWJ6kKPsaAg5iCGWU4CqBigSJ2YoEiFiiCgshQsunVQ_7cj6j_Wv5QyIK3JwHmVx4MBhGVQadQm4AqCe3N__Pf_WNX1jijpN3jEePOz8Hl_xMgYimouFvaYukKaCsKeah-A1gMtAs</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Dutta, Debarun</creator><creator>Zhao, Timothy</creator><creator>Cheah, Kai Bing</creator><creator>Holmlund, Larke</creator><creator>Willcox, Mark D.P</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170601</creationdate><title>Activity of a melimine derived peptide Mel4 against Stenotrophomonas, Delftia, Elizabethkingia, Burkholderia and biocompatibility as a contact lens coating</title><author>Dutta, Debarun ; Zhao, Timothy ; Cheah, Kai Bing ; Holmlund, Larke ; Willcox, Mark D.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-2b89895b7e1df45191d9a04aa03f653e9c5289770750760534a69dbb721f7d383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Antimicrobial</topic><topic>Antimicrobial Cationic Peptides - pharmacology</topic><topic>Bacterial Adhesion - drug effects</topic><topic>Burkholderia - drug effects</topic><topic>Burkholderia - isolation & purification</topic><topic>Burkholderia Infections - microbiology</topic><topic>Burkholderia Infections - prevention & control</topic><topic>Coated Materials, Biocompatible - chemistry</topic><topic>Contact lens</topic><topic>Contact Lenses - microbiology</topic><topic>Delftia</topic><topic>Disease Models, Animal</topic><topic>Equipment Contamination - prevention & control</topic><topic>Eye Infections, Bacterial - microbiology</topic><topic>Eye Infections, Bacterial - prevention & control</topic><topic>Female</topic><topic>Gram-Negative Bacterial Infections - microbiology</topic><topic>Gram-Negative Bacterial Infections - prevention & control</topic><topic>Materials Testing - methods</topic><topic>Mel4</topic><topic>Melimine</topic><topic>Microbial Sensitivity Tests - methods</topic><topic>Ophthalmology</topic><topic>Prospective Studies</topic><topic>Rabbits</topic><topic>Stenotrophomonas</topic><topic>Stenotrophomonas - drug effects</topic><topic>Stenotrophomonas - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dutta, Debarun</creatorcontrib><creatorcontrib>Zhao, Timothy</creatorcontrib><creatorcontrib>Cheah, Kai Bing</creatorcontrib><creatorcontrib>Holmlund, Larke</creatorcontrib><creatorcontrib>Willcox, Mark D.P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Contact lens & anterior eye</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dutta, Debarun</au><au>Zhao, Timothy</au><au>Cheah, Kai Bing</au><au>Holmlund, Larke</au><au>Willcox, Mark D.P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activity of a melimine derived peptide Mel4 against Stenotrophomonas, Delftia, Elizabethkingia, Burkholderia and biocompatibility as a contact lens coating</atitle><jtitle>Contact lens & anterior eye</jtitle><addtitle>Cont Lens Anterior Eye</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>40</volume><issue>3</issue><spage>175</spage><epage>183</epage><pages>175-183</pages><issn>1367-0484</issn><eissn>1476-5411</eissn><abstract>Highlights • Mel4 contact lens coating retain high activity against Delftia, Stenotrophomonas, Elizabethkingia, Burkholderia. • Mel4 coated antimicrobial contact lenses are biocompatible during 22 days rabbit lens wear. • These lenses did not show increased redness or corneal staining during 1 week daily wear for humans.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>28118996</pmid><doi>10.1016/j.clae.2017.01.002</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1367-0484 |
| ispartof | Contact lens & anterior eye, 2017-06, Vol.40 (3), p.175-183 |
| issn | 1367-0484 1476-5411 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antimicrobial Antimicrobial Cationic Peptides - pharmacology Bacterial Adhesion - drug effects Burkholderia - drug effects Burkholderia - isolation & purification Burkholderia Infections - microbiology Burkholderia Infections - prevention & control Coated Materials, Biocompatible - chemistry Contact lens Contact Lenses - microbiology Delftia Disease Models, Animal Equipment Contamination - prevention & control Eye Infections, Bacterial - microbiology Eye Infections, Bacterial - prevention & control Female Gram-Negative Bacterial Infections - microbiology Gram-Negative Bacterial Infections - prevention & control Materials Testing - methods Mel4 Melimine Microbial Sensitivity Tests - methods Ophthalmology Prospective Studies Rabbits Stenotrophomonas Stenotrophomonas - drug effects Stenotrophomonas - isolation & purification |
| title | Activity of a melimine derived peptide Mel4 against Stenotrophomonas, Delftia, Elizabethkingia, Burkholderia and biocompatibility as a contact lens coating |
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