Activity of a melimine derived peptide Mel4 against Stenotrophomonas, Delftia, Elizabethkingia, Burkholderia and biocompatibility as a contact lens coating

Highlights • Mel4 contact lens coating retain high activity against Delftia, Stenotrophomonas, Elizabethkingia, Burkholderia. • Mel4 coated antimicrobial contact lenses are biocompatible during 22 days rabbit lens wear. • These lenses did not show increased redness or corneal staining during 1 week...

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Veröffentlicht in:	Contact lens & anterior eye 2017-06, Vol.40 (3), p.175-183
Hauptverfasser:	Dutta, Debarun, Zhao, Timothy, Cheah, Kai Bing, Holmlund, Larke, Willcox, Mark D.P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimicrobial Antimicrobial Cationic Peptides - pharmacology Bacterial Adhesion - drug effects Burkholderia - drug effects Burkholderia - isolation & purification Burkholderia Infections - microbiology Burkholderia Infections - prevention & control Coated Materials, Biocompatible - chemistry Contact lens Contact Lenses - microbiology Delftia Disease Models, Animal Equipment Contamination - prevention & control Eye Infections, Bacterial - microbiology Eye Infections, Bacterial - prevention & control Female Gram-Negative Bacterial Infections - microbiology Gram-Negative Bacterial Infections - prevention & control Materials Testing - methods Mel4 Melimine Microbial Sensitivity Tests - methods Ophthalmology Prospective Studies Rabbits Stenotrophomonas Stenotrophomonas - drug effects Stenotrophomonas - isolation & purification
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Beschreibung
Zusammenfassung:	Highlights • Mel4 contact lens coating retain high activity against Delftia, Stenotrophomonas, Elizabethkingia, Burkholderia. • Mel4 coated antimicrobial contact lenses are biocompatible during 22 days rabbit lens wear. • These lenses did not show increased redness or corneal staining during 1 week daily wear for humans.
ISSN:	1367-0484 1476-5411
DOI:	10.1016/j.clae.2017.01.002