Structural brain alteration in survivors of acute lymphoblastic leukemia with chemotherapy treatment: a voxel-based morphometry and diffusion tensor imaging study
Highlights • ALL chemotherapy survivors exhibited GM alterations. • WM integrity changes through lower FA and AD value, higher MD and RD values in ALL patients. • VBM and DTI can reveal GM and WM alteration in ALL patients.
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| Veröffentlicht in: | Brain research 2017-03, Vol.1658, p.68-72 |
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| container_title | Brain research |
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| creator | Zou, Liwei Su, Lianzi Xu, Jiajia Xiang, Li Wang, Longsheng Zhai, Zhimin Zheng, Suisheng |
| description | Highlights • ALL chemotherapy survivors exhibited GM alterations. • WM integrity changes through lower FA and AD value, higher MD and RD values in ALL patients. • VBM and DTI can reveal GM and WM alteration in ALL patients. |
| doi_str_mv | 10.1016/j.brainres.2017.01.017 |
| format | Article |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Acute lymphoblastic leukemia Adult Antineoplastic Agents - therapeutic use Antineoplastic Agents - toxicity Brain - diagnostic imaging Brain - drug effects Chemotherapy Diffusion Tensor Imaging Female Gray Matter - diagnostic imaging Gray Matter - drug effects Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Neurology Organ Size Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnostic imaging Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Survivors Tract-based spatial statistics Voxel-based morphometry White Matter - diagnostic imaging White Matter - drug effects |
| title | Structural brain alteration in survivors of acute lymphoblastic leukemia with chemotherapy treatment: a voxel-based morphometry and diffusion tensor imaging study |
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