Structural brain alteration in survivors of acute lymphoblastic leukemia with chemotherapy treatment: a voxel-based morphometry and diffusion tensor imaging study

Highlights • ALL chemotherapy survivors exhibited GM alterations. • WM integrity changes through lower FA and AD value, higher MD and RD values in ALL patients. • VBM and DTI can reveal GM and WM alteration in ALL patients.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain research 2017-03, Vol.1658, p.68-72
Hauptverfasser:	Zou, Liwei, Su, Lianzi, Xu, Jiajia, Xiang, Li, Wang, Longsheng, Zhai, Zhimin, Zheng, Suisheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Adult Antineoplastic Agents - therapeutic use Antineoplastic Agents - toxicity Brain - diagnostic imaging Brain - drug effects Chemotherapy Diffusion Tensor Imaging Female Gray Matter - diagnostic imaging Gray Matter - drug effects Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Neurology Organ Size Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnostic imaging Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Survivors Tract-based spatial statistics Voxel-based morphometry White Matter - diagnostic imaging White Matter - drug effects
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Beschreibung
Zusammenfassung:	Highlights • ALL chemotherapy survivors exhibited GM alterations. • WM integrity changes through lower FA and AD value, higher MD and RD values in ALL patients. • VBM and DTI can reveal GM and WM alteration in ALL patients.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2017.01.017