Therapeutic implication of mTORC2 in oral squamous cell carcinoma

Highlights • mTORC2 axis expression is associated with cancer progression. • Torin-1 inhibits proliferation of oral squamous cell carcinoma cells. • Combined Torin-1 and cetuximab treatment may have additional therapeutic benefit.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oral oncology 2017-02, Vol.65, p.23-32
Hauptverfasser:	Naruse, Tomofumi, Yanamoto, Souichi, Okuyama, Kohei, Yamashita, Kentaro, Omori, Keisuke, Nakao, Yuji, Yamada, Shin-ichi, Umeda, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Proliferation Cetuximab Female Hematology, Oncology and Palliative Medicine Humans Male Mechanistic Target of Rapamycin Complex 2 - metabolism Mice Mice, Inbred BALB C Mice, Nude Mouth Neoplasms - drug therapy Mouth Neoplasms - metabolism Mouth Neoplasms - pathology mTORC2 Otolaryngology Rictor SGK1 Torin-1
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • mTORC2 axis expression is associated with cancer progression. • Torin-1 inhibits proliferation of oral squamous cell carcinoma cells. • Combined Torin-1 and cetuximab treatment may have additional therapeutic benefit.
ISSN:	1368-8375 1879-0593
DOI:	10.1016/j.oraloncology.2016.12.012