Basic Study for the Purpose of Developing a Quantitative 67Ga-SPECT Measurement Method
Purpose: 67Ga-single photon emission computed tomography (SPECT) images vary according to the imaging time and image display methods. The calculation of an index, such as the standardized uptake value used in positron emission tomography, from 67Ga-SPECT images would enable the accurate evaluation o...
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| Veröffentlicht in: | Japanese Journal of Radiological Technology 2017, Vol.73(1), pp.12-19 |
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| creator | Nakanishi, Kensuke Sakata, Reiki Takaki, Akihiro Nakasone, Yutaka Kadota, Masataka Ito, Shigeki |
| description | Purpose: 67Ga-single photon emission computed tomography (SPECT) images vary according to the imaging time and image display methods. The calculation of an index, such as the standardized uptake value used in positron emission tomography, from 67Ga-SPECT images would enable the accurate evaluation of the region of accumulation. The purpose of this study was to elucidate the conversion formula, the lower detection limit (LDL), and recovery coefficient (RC) for quantifying the radiation concentration in the 67Ga accumulation site. Methods: After chronologically obtaining SPECT/CT images at a radiation concentration of 1.0–442.4 kBq/mL with 27 bottles (diameter: 48 mm, 100 mL), the radiation concentration conversion formula was calculated using the successive approximation reconstruction method. The conversion coefficient was then calculated from the relationship between the count rate and the radiation concentration, and the LDL was determined. To compensate for the partial volume effect, the recovery curve was calculated using the mean SPECT count for six bottles (diameter: 9, 18, 29, 38, 48, and 94 mm). Results: There was a linear relationship between the radiation concentration and the count rate with a good correlation (r=0.99). The LDL was 1.0 kBq/mL. The recovery curve reached a plateau at a diameter of at least 48 mm. Conclusion: The calculation of the absorbed dose index was possible using the radiation concentration conversion formula and the RC. |
| doi_str_mv | 10.6009/jjrt.2017_JSRT_73.1.12 |
| format | Article |
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The calculation of an index, such as the standardized uptake value used in positron emission tomography, from 67Ga-SPECT images would enable the accurate evaluation of the region of accumulation. The purpose of this study was to elucidate the conversion formula, the lower detection limit (LDL), and recovery coefficient (RC) for quantifying the radiation concentration in the 67Ga accumulation site. Methods: After chronologically obtaining SPECT/CT images at a radiation concentration of 1.0–442.4 kBq/mL with 27 bottles (diameter: 48 mm, 100 mL), the radiation concentration conversion formula was calculated using the successive approximation reconstruction method. The conversion coefficient was then calculated from the relationship between the count rate and the radiation concentration, and the LDL was determined. To compensate for the partial volume effect, the recovery curve was calculated using the mean SPECT count for six bottles (diameter: 9, 18, 29, 38, 48, and 94 mm). Results: There was a linear relationship between the radiation concentration and the count rate with a good correlation (r=0.99). The LDL was 1.0 kBq/mL. The recovery curve reached a plateau at a diameter of at least 48 mm. Conclusion: The calculation of the absorbed dose index was possible using the radiation concentration conversion formula and the RC.</description><identifier>ISSN: 0369-4305</identifier><identifier>EISSN: 1881-4883</identifier><identifier>DOI: 10.6009/jjrt.2017_JSRT_73.1.12</identifier><language>eng ; jpn</language><publisher>Kyoto: Japanese Society of Radiological Technology</publisher><subject>67Ga-citrate ; Accumulation ; Bottles ; Computed tomography ; Conversion ; Emission analysis ; Emission measurements ; Image reconstruction ; Low density lipoprotein ; lower detection limit (LDL) ; Mathematical analysis ; Medical imaging ; Photon emission ; Positron emission ; Positron emission tomography ; Radiation ; radioactivity conversion coefficient ; Recovery ; recovery coefficient (RC) ; Single photon emission computed tomography ; single photon emission computed tomography (SPECT) ; Tomography</subject><ispartof>Japanese Journal of Radiological Technology, 2017, Vol.73(1), pp.12-19</ispartof><rights>2017 Japanese Society of Radiological Technology</rights><rights>Copyright Japan Science and Technology Agency 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2252-ff46e4ed36edeb9afa457ca0e16dce661d48c0dd91818549c9eba9149ec4a0043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>Nakanishi, Kensuke</creatorcontrib><creatorcontrib>Sakata, Reiki</creatorcontrib><creatorcontrib>Takaki, Akihiro</creatorcontrib><creatorcontrib>Nakasone, Yutaka</creatorcontrib><creatorcontrib>Kadota, Masataka</creatorcontrib><creatorcontrib>Ito, Shigeki</creatorcontrib><title>Basic Study for the Purpose of Developing a Quantitative 67Ga-SPECT Measurement Method</title><title>Japanese Journal of Radiological Technology</title><addtitle>Jpn. J. Radiol. Technol.</addtitle><description>Purpose: 67Ga-single photon emission computed tomography (SPECT) images vary according to the imaging time and image display methods. The calculation of an index, such as the standardized uptake value used in positron emission tomography, from 67Ga-SPECT images would enable the accurate evaluation of the region of accumulation. The purpose of this study was to elucidate the conversion formula, the lower detection limit (LDL), and recovery coefficient (RC) for quantifying the radiation concentration in the 67Ga accumulation site. Methods: After chronologically obtaining SPECT/CT images at a radiation concentration of 1.0–442.4 kBq/mL with 27 bottles (diameter: 48 mm, 100 mL), the radiation concentration conversion formula was calculated using the successive approximation reconstruction method. The conversion coefficient was then calculated from the relationship between the count rate and the radiation concentration, and the LDL was determined. To compensate for the partial volume effect, the recovery curve was calculated using the mean SPECT count for six bottles (diameter: 9, 18, 29, 38, 48, and 94 mm). Results: There was a linear relationship between the radiation concentration and the count rate with a good correlation (r=0.99). The LDL was 1.0 kBq/mL. The recovery curve reached a plateau at a diameter of at least 48 mm. Conclusion: The calculation of the absorbed dose index was possible using the radiation concentration conversion formula and the RC.</description><subject>67Ga-citrate</subject><subject>Accumulation</subject><subject>Bottles</subject><subject>Computed tomography</subject><subject>Conversion</subject><subject>Emission analysis</subject><subject>Emission measurements</subject><subject>Image reconstruction</subject><subject>Low density lipoprotein</subject><subject>lower detection limit (LDL)</subject><subject>Mathematical analysis</subject><subject>Medical imaging</subject><subject>Photon emission</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Radiation</subject><subject>radioactivity conversion coefficient</subject><subject>Recovery</subject><subject>recovery coefficient (RC)</subject><subject>Single photon emission computed tomography</subject><subject>single photon emission computed tomography (SPECT)</subject><subject>Tomography</subject><issn>0369-4305</issn><issn>1881-4883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNplkFFv0zAQxy0EEtXYV0CWeOElxec4jv0IZRugIra18GpdncuaKo2L7UzatyelaELby93p9PudTn_G3oKYayHsh90u5rkUULtvq9u1q8s5zEG-YDMwBgplTPmSzUSpbaFKUb1m5yl1GzGZ00qoGfv1CVPn-SqPzQNvQ-R5S_x6jIeQiIeWf6Z76sOhG-448psRh9xlzN09cV1fYbG6vlis-XfCNEba05CnOW9D84a9arFPdP6vn7GflxfrxZdi-ePq6-LjsvBSVrJoW6VJUVNqamhjsUVV1R4FgW48aQ2NMl40jQUDplLWW9qgBWXJKxRClWfs_enuIYbfI6Xs9l3y1Pc4UBiTA6OhsqqCckLfPUF3YYzD9J2TUpq6klbJidInyseQUqTWHWK3x_jgQLhj4u6YuPs_cQcOjuLyJO5Sxjt61DDmzvd00v7CU3mmP2J-i9HRUP4BwcSQjw</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Nakanishi, Kensuke</creator><creator>Sakata, Reiki</creator><creator>Takaki, Akihiro</creator><creator>Nakasone, Yutaka</creator><creator>Kadota, Masataka</creator><creator>Ito, Shigeki</creator><general>Japanese Society of Radiological Technology</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SC</scope><scope>7U5</scope><scope>8FD</scope><scope>FR3</scope><scope>JQ2</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2017</creationdate><title>Basic Study for the Purpose of Developing a Quantitative 67Ga-SPECT Measurement Method</title><author>Nakanishi, Kensuke ; Sakata, Reiki ; Takaki, Akihiro ; Nakasone, Yutaka ; Kadota, Masataka ; Ito, Shigeki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2252-ff46e4ed36edeb9afa457ca0e16dce661d48c0dd91818549c9eba9149ec4a0043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>2017</creationdate><topic>67Ga-citrate</topic><topic>Accumulation</topic><topic>Bottles</topic><topic>Computed tomography</topic><topic>Conversion</topic><topic>Emission analysis</topic><topic>Emission measurements</topic><topic>Image reconstruction</topic><topic>Low density lipoprotein</topic><topic>lower detection limit (LDL)</topic><topic>Mathematical analysis</topic><topic>Medical imaging</topic><topic>Photon emission</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Radiation</topic><topic>radioactivity conversion coefficient</topic><topic>Recovery</topic><topic>recovery coefficient (RC)</topic><topic>Single photon emission computed tomography</topic><topic>single photon emission computed tomography (SPECT)</topic><topic>Tomography</topic><toplevel>online_resources</toplevel><creatorcontrib>Nakanishi, Kensuke</creatorcontrib><creatorcontrib>Sakata, Reiki</creatorcontrib><creatorcontrib>Takaki, Akihiro</creatorcontrib><creatorcontrib>Nakasone, Yutaka</creatorcontrib><creatorcontrib>Kadota, Masataka</creatorcontrib><creatorcontrib>Ito, Shigeki</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese Journal of Radiological Technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakanishi, Kensuke</au><au>Sakata, Reiki</au><au>Takaki, Akihiro</au><au>Nakasone, Yutaka</au><au>Kadota, Masataka</au><au>Ito, Shigeki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Basic Study for the Purpose of Developing a Quantitative 67Ga-SPECT Measurement Method</atitle><jtitle>Japanese Journal of Radiological Technology</jtitle><addtitle>Jpn. J. Radiol. Technol.</addtitle><date>2017</date><risdate>2017</risdate><volume>73</volume><issue>1</issue><spage>12</spage><epage>19</epage><pages>12-19</pages><issn>0369-4305</issn><eissn>1881-4883</eissn><abstract>Purpose: 67Ga-single photon emission computed tomography (SPECT) images vary according to the imaging time and image display methods. The calculation of an index, such as the standardized uptake value used in positron emission tomography, from 67Ga-SPECT images would enable the accurate evaluation of the region of accumulation. The purpose of this study was to elucidate the conversion formula, the lower detection limit (LDL), and recovery coefficient (RC) for quantifying the radiation concentration in the 67Ga accumulation site. Methods: After chronologically obtaining SPECT/CT images at a radiation concentration of 1.0–442.4 kBq/mL with 27 bottles (diameter: 48 mm, 100 mL), the radiation concentration conversion formula was calculated using the successive approximation reconstruction method. The conversion coefficient was then calculated from the relationship between the count rate and the radiation concentration, and the LDL was determined. To compensate for the partial volume effect, the recovery curve was calculated using the mean SPECT count for six bottles (diameter: 9, 18, 29, 38, 48, and 94 mm). Results: There was a linear relationship between the radiation concentration and the count rate with a good correlation (r=0.99). The LDL was 1.0 kBq/mL. The recovery curve reached a plateau at a diameter of at least 48 mm. Conclusion: The calculation of the absorbed dose index was possible using the radiation concentration conversion formula and the RC.</abstract><cop>Kyoto</cop><pub>Japanese Society of Radiological Technology</pub><doi>10.6009/jjrt.2017_JSRT_73.1.12</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 67Ga-citrate Accumulation Bottles Computed tomography Conversion Emission analysis Emission measurements Image reconstruction Low density lipoprotein lower detection limit (LDL) Mathematical analysis Medical imaging Photon emission Positron emission Positron emission tomography Radiation radioactivity conversion coefficient Recovery recovery coefficient (RC) Single photon emission computed tomography single photon emission computed tomography (SPECT) Tomography |
| title | Basic Study for the Purpose of Developing a Quantitative 67Ga-SPECT Measurement Method |
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