Evaluation of the antimicrobial activity of the mastoparan Polybia-MPII isolated from venom of the social wasp Pseudopolybia vespiceps testacea (Vespidae, Hymenoptera)

Highlights • Polybia-MPII demonstrated potent activity against Staphylococcus aureus. • Topical application of Polybia-MPII reduced the number of S. aureus in wounds. • Polybia-MPII inhibited the growth of two medically important fungal pathogens. • Polybia-MPII has potential to inhibit mycobacteria...

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Veröffentlicht in:	International journal of antimicrobial agents 2017-02, Vol.49 (2), p.167-175
Hauptverfasser:	Silva, Juliana Castro e, Neto, Lázaro Moreira Marques, Neves, Rogério Coutinho das, Gonçalves, Jaqueline Coimbra, Trentini, Monalisa Martins, Mucury-Filho, Ricardo, Smidt, Karina Simon, Fensterseifer, Isabel Cristina Marques, Silva, Osmar Nascimento, Lima, Lilian Daiene Mota, Clissa, Patricia Bianca, Vilela, Nathália, Guilhelmelli, Fernanda, Silva, Luciano Paulino, Rangel, Marisa, Kipnis, André, Silva-Pereira, Ildinete, Franco, Octavio Luiz, Junqueira-Kipnis, Ana Paula, Bocca, Anamelia Lorenzetti, Mortari, Márcia Renata
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology Bacteria - drug effects Candida albicans Cryptococcus neoformans Disease Models, Animal Female Fungi - drug effects Healthy Volunteers Humans Infectious Disease Macrophages, Peritoneal - microbiology Mice, Inbred BALB C Mice, Inbred C57BL Microbial Sensitivity Tests Microbial Viability - drug effects Mycobacterium abscessus subsp. massiliense Peptide Peptides - isolation & purification Peptides - pharmacology Staphylococcal Infections - drug therapy Staphylococcus aureus Treatment Outcome Wasp venom Wasp Venoms - isolation & purification Wasp Venoms - pharmacology Wasps - chemistry
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Beschreibung
Zusammenfassung:	Highlights • Polybia-MPII demonstrated potent activity against Staphylococcus aureus. • Topical application of Polybia-MPII reduced the number of S. aureus in wounds. • Polybia-MPII inhibited the growth of two medically important fungal pathogens. • Polybia-MPII has potential to inhibit mycobacteria and to kill intracytoplasmic bacteria. • The peptide presented lytic pore-forming activity on planar lipid bilayers.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2016.11.013