Determination of sulfonamides in animal tissues by modified QuEChERS and liquid chromatography tandem mass spectrometry

In this study, the salting-out solvent extraction and dispersive solid-phase extraction (dSPE) clean-up steps in QuEChERS (quick, easy, cheap, effective, rugged, and safe) method were optimized to reduce matrix effect and efficiently extract target sulfonamides from a variety of edible animal tissues. The extracted sulfonamides were then analyzed using liquid chromatography tandem mass spectrometry (LC-MS/MS). Good extraction recoveries (74.0−100.3% in five different sources of animal tissues; n=3) with acceptable matrix effect (