AAZTA: An Ideal Chelating Agent for the Development of 44 Sc PET Imaging Agents
Unprecedented fast and efficient complexation of Sc was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the Sc(AAZTA) chelate and conjugated biomolecules thereo...
Gespeichert in:
| Veröffentlicht in: | Angewandte Chemie International Edition 2017-02, Vol.56 (8), p.2118-2122 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2122 |
|---|---|
| container_issue | 8 |
| container_start_page | 2118 |
| container_title | Angewandte Chemie International Edition |
| container_volume | 56 |
| creator | Nagy, Gábor Szikra, Dezső Trencsényi, György Fekete, Anikó Garai, Ildikó Giani, Arianna M Negri, Roberto Masciocchi, Norberto Maiocchi, Alessandro Uggeri, Fulvio Tóth, Imre Aime, Silvio Giovenzana, Giovanni B Baranyai, Zsolt |
| description | Unprecedented fast and efficient complexation of Sc
was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the
Sc(AAZTA)
chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator. |
| doi_str_mv | 10.1002/anie.201611207 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1861570291</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1861570291</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1406-2659dc20ba742b46bb9f869f0aa04e766754bcfc25a86abdc4d909b1924c6fbe3</originalsourceid><addsrcrecordid>eNo9kDtPwzAUhS0EoqWwMiKPLCm24_jBFpUClSoVibKwRLZz3QblUeIEiX9PqpZO5-rou2f4ELqlZEoJYQ-mLmDKCBWUMiLP0JgmjEaxlPH5cPM4jqRK6AhdhfA18EoRcYlGTBEtZSLGaJWmn-v0Eac1XuRgSjzbQmm6ot7gdAN1h33T4m4L-Al-oGx21b5rPOYcvzv8Nl_jRWU2JzxcowtvygA3x5ygj-f5evYaLVcvi1m6jBzlRERMJDp3jFgjObNcWKu9EtoTYwgHKYRMuHXescQoYWzueK6JtlQz7oS3EE_Q_WF31zbfPYQuq4rgoCxNDU0fMqoETSRhmg7o9IC6tgmhBZ_t2qIy7W9GSbaXmO0lZieJw8Pdcbu3FeQn_N9a_AcLjmp0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1861570291</pqid></control><display><type>article</type><title>AAZTA: An Ideal Chelating Agent for the Development of 44 Sc PET Imaging Agents</title><source>Access via Wiley Online Library</source><creator>Nagy, Gábor ; Szikra, Dezső ; Trencsényi, György ; Fekete, Anikó ; Garai, Ildikó ; Giani, Arianna M ; Negri, Roberto ; Masciocchi, Norberto ; Maiocchi, Alessandro ; Uggeri, Fulvio ; Tóth, Imre ; Aime, Silvio ; Giovenzana, Giovanni B ; Baranyai, Zsolt</creator><creatorcontrib>Nagy, Gábor ; Szikra, Dezső ; Trencsényi, György ; Fekete, Anikó ; Garai, Ildikó ; Giani, Arianna M ; Negri, Roberto ; Masciocchi, Norberto ; Maiocchi, Alessandro ; Uggeri, Fulvio ; Tóth, Imre ; Aime, Silvio ; Giovenzana, Giovanni B ; Baranyai, Zsolt</creatorcontrib><description>Unprecedented fast and efficient complexation of Sc
was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the
Sc(AAZTA)
chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.</description><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201611207</identifier><identifier>PMID: 28097756</identifier><language>eng</language><publisher>Germany</publisher><ispartof>Angewandte Chemie International Edition, 2017-02, Vol.56 (8), p.2118-2122</ispartof><rights>2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1406-2659dc20ba742b46bb9f869f0aa04e766754bcfc25a86abdc4d909b1924c6fbe3</citedby><cites>FETCH-LOGICAL-c1406-2659dc20ba742b46bb9f869f0aa04e766754bcfc25a86abdc4d909b1924c6fbe3</cites><orcidid>0000-0001-7117-0347 ; 0000-0002-6792-8992 ; 0000-0001-6844-7974 ; 0000-0001-9921-2350</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28097756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagy, Gábor</creatorcontrib><creatorcontrib>Szikra, Dezső</creatorcontrib><creatorcontrib>Trencsényi, György</creatorcontrib><creatorcontrib>Fekete, Anikó</creatorcontrib><creatorcontrib>Garai, Ildikó</creatorcontrib><creatorcontrib>Giani, Arianna M</creatorcontrib><creatorcontrib>Negri, Roberto</creatorcontrib><creatorcontrib>Masciocchi, Norberto</creatorcontrib><creatorcontrib>Maiocchi, Alessandro</creatorcontrib><creatorcontrib>Uggeri, Fulvio</creatorcontrib><creatorcontrib>Tóth, Imre</creatorcontrib><creatorcontrib>Aime, Silvio</creatorcontrib><creatorcontrib>Giovenzana, Giovanni B</creatorcontrib><creatorcontrib>Baranyai, Zsolt</creatorcontrib><title>AAZTA: An Ideal Chelating Agent for the Development of 44 Sc PET Imaging Agents</title><title>Angewandte Chemie International Edition</title><addtitle>Angew Chem Int Ed Engl</addtitle><description>Unprecedented fast and efficient complexation of Sc
was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the
Sc(AAZTA)
chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.</description><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNo9kDtPwzAUhS0EoqWwMiKPLCm24_jBFpUClSoVibKwRLZz3QblUeIEiX9PqpZO5-rou2f4ELqlZEoJYQ-mLmDKCBWUMiLP0JgmjEaxlPH5cPM4jqRK6AhdhfA18EoRcYlGTBEtZSLGaJWmn-v0Eac1XuRgSjzbQmm6ot7gdAN1h33T4m4L-Al-oGx21b5rPOYcvzv8Nl_jRWU2JzxcowtvygA3x5ygj-f5evYaLVcvi1m6jBzlRERMJDp3jFgjObNcWKu9EtoTYwgHKYRMuHXescQoYWzueK6JtlQz7oS3EE_Q_WF31zbfPYQuq4rgoCxNDU0fMqoETSRhmg7o9IC6tgmhBZ_t2qIy7W9GSbaXmO0lZieJw8Pdcbu3FeQn_N9a_AcLjmp0</recordid><startdate>20170213</startdate><enddate>20170213</enddate><creator>Nagy, Gábor</creator><creator>Szikra, Dezső</creator><creator>Trencsényi, György</creator><creator>Fekete, Anikó</creator><creator>Garai, Ildikó</creator><creator>Giani, Arianna M</creator><creator>Negri, Roberto</creator><creator>Masciocchi, Norberto</creator><creator>Maiocchi, Alessandro</creator><creator>Uggeri, Fulvio</creator><creator>Tóth, Imre</creator><creator>Aime, Silvio</creator><creator>Giovenzana, Giovanni B</creator><creator>Baranyai, Zsolt</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7117-0347</orcidid><orcidid>https://orcid.org/0000-0002-6792-8992</orcidid><orcidid>https://orcid.org/0000-0001-6844-7974</orcidid><orcidid>https://orcid.org/0000-0001-9921-2350</orcidid></search><sort><creationdate>20170213</creationdate><title>AAZTA: An Ideal Chelating Agent for the Development of 44 Sc PET Imaging Agents</title><author>Nagy, Gábor ; Szikra, Dezső ; Trencsényi, György ; Fekete, Anikó ; Garai, Ildikó ; Giani, Arianna M ; Negri, Roberto ; Masciocchi, Norberto ; Maiocchi, Alessandro ; Uggeri, Fulvio ; Tóth, Imre ; Aime, Silvio ; Giovenzana, Giovanni B ; Baranyai, Zsolt</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1406-2659dc20ba742b46bb9f869f0aa04e766754bcfc25a86abdc4d909b1924c6fbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagy, Gábor</creatorcontrib><creatorcontrib>Szikra, Dezső</creatorcontrib><creatorcontrib>Trencsényi, György</creatorcontrib><creatorcontrib>Fekete, Anikó</creatorcontrib><creatorcontrib>Garai, Ildikó</creatorcontrib><creatorcontrib>Giani, Arianna M</creatorcontrib><creatorcontrib>Negri, Roberto</creatorcontrib><creatorcontrib>Masciocchi, Norberto</creatorcontrib><creatorcontrib>Maiocchi, Alessandro</creatorcontrib><creatorcontrib>Uggeri, Fulvio</creatorcontrib><creatorcontrib>Tóth, Imre</creatorcontrib><creatorcontrib>Aime, Silvio</creatorcontrib><creatorcontrib>Giovenzana, Giovanni B</creatorcontrib><creatorcontrib>Baranyai, Zsolt</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagy, Gábor</au><au>Szikra, Dezső</au><au>Trencsényi, György</au><au>Fekete, Anikó</au><au>Garai, Ildikó</au><au>Giani, Arianna M</au><au>Negri, Roberto</au><au>Masciocchi, Norberto</au><au>Maiocchi, Alessandro</au><au>Uggeri, Fulvio</au><au>Tóth, Imre</au><au>Aime, Silvio</au><au>Giovenzana, Giovanni B</au><au>Baranyai, Zsolt</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>AAZTA: An Ideal Chelating Agent for the Development of 44 Sc PET Imaging Agents</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew Chem Int Ed Engl</addtitle><date>2017-02-13</date><risdate>2017</risdate><volume>56</volume><issue>8</issue><spage>2118</spage><epage>2122</epage><pages>2118-2122</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><abstract>Unprecedented fast and efficient complexation of Sc
was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the
Sc(AAZTA)
chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.</abstract><cop>Germany</cop><pmid>28097756</pmid><doi>10.1002/anie.201611207</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-7117-0347</orcidid><orcidid>https://orcid.org/0000-0002-6792-8992</orcidid><orcidid>https://orcid.org/0000-0001-6844-7974</orcidid><orcidid>https://orcid.org/0000-0001-9921-2350</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie International Edition, 2017-02, Vol.56 (8), p.2118-2122 |
| issn | 1433-7851 1521-3773 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1861570291 |
| source | Access via Wiley Online Library |
| title | AAZTA: An Ideal Chelating Agent for the Development of 44 Sc PET Imaging Agents |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T18%3A39%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=AAZTA:%20An%20Ideal%20Chelating%20Agent%20for%20the%20Development%20of%2044%20Sc%20PET%20Imaging%20Agents&rft.jtitle=Angewandte%20Chemie%20International%20Edition&rft.au=Nagy,%20G%C3%A1bor&rft.date=2017-02-13&rft.volume=56&rft.issue=8&rft.spage=2118&rft.epage=2122&rft.pages=2118-2122&rft.issn=1433-7851&rft.eissn=1521-3773&rft_id=info:doi/10.1002/anie.201611207&rft_dat=%3Cproquest_cross%3E1861570291%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1861570291&rft_id=info:pmid/28097756&rfr_iscdi=true |