AAZTA: An Ideal Chelating Agent for the Development of 44 Sc PET Imaging Agents

AAZTA: An Ideal Chelating Agent for the Development of 44 Sc PET Imaging Agents

Unprecedented fast and efficient complexation of Sc was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the Sc(AAZTA) chelate and conjugated biomolecules thereo...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2017-02, Vol.56 (8), p.2118-2122
Hauptverfasser: Nagy, Gábor, Szikra, Dezső, Trencsényi, György, Fekete, Anikó, Garai, Ildikó, Giani, Arianna M, Negri, Roberto, Masciocchi, Norberto, Maiocchi, Alessandro, Uggeri, Fulvio, Tóth, Imre, Aime, Silvio, Giovenzana, Giovanni B, Baranyai, Zsolt
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Unprecedented fast and efficient complexation of Sc was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the Sc(AAZTA) chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201611207