Galectins: emerging regulatory checkpoints linking tumor immunity and angiogenesis

Highlights • Galectins engage a number of glycosylated immune checkpoint receptors. • Galectins alter T-cell and NK-cell activation, signaling and survival. • Galectins endow myeloid cells with immune regulatory potential. • Glycosylation-dependent galectin–receptor interactions control angiogenesis...

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Veröffentlicht in:	Current opinion in immunology 2017-04, Vol.45, p.8-15
Hauptverfasser:	Méndez-Huergo, Santiago P, Blidner, Ada G, Rabinovich, Gabriel A
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Galectins - immunology Humans Killer Cells, Natural - immunology Killer Cells, Natural - pathology Neoplasms - blood supply Neoplasms - immunology Neoplasms - pathology Neovascularization, Pathologic - immunology Neovascularization, Pathologic - pathology T-Lymphocytes - immunology T-Lymphocytes - pathology
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Beschreibung
Zusammenfassung:	Highlights • Galectins engage a number of glycosylated immune checkpoint receptors. • Galectins alter T-cell and NK-cell activation, signaling and survival. • Galectins endow myeloid cells with immune regulatory potential. • Glycosylation-dependent galectin–receptor interactions control angiogenesis. • Galectin–glycan interactions confer resistance to anti-cancer therapies.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2016.12.003