Microglia-derived neuregulin expression in psychiatric disorders

Highlights • Neuregulins (NRGs) are expressed in microglia. • Microglial NRG expression is significantly increased in BTBR and socially isolated mice. • NRG1 type III levels in PBMCs are correlated with scores of ADI-R domain A.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2017-03, Vol.61, p.375-385
Hauptverfasser:	Ikawa, Daisuke, Makinodan, Manabu, Iwata, Keiko, Ohgidani, Masahiro, Kato, Takahiro A, Yamashita, Yasunori, Yamamuro, Kazuhiko, Kimoto, Sohei, Toritsuka, Michihiro, Yamauchi, Takahira, Fukami, Shin-ichi, Yoshino, Hiroki, Okumura, Kazuki, Tanaka, Tatsuhide, Wanaka, Akio, Owada, Yuji, Tsujii, Masatsugu, Sugiyama, Toshiro, Tsuchiya, Kenji, Mori, Norio, Hashimoto, Ryota, Matsuzaki, Hideo, Kanba, Shigenobu, Kishimoto, Toshifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Allergy and Immunology Animals Autism spectrum disorder Autism Spectrum Disorder - genetics Autism Spectrum Disorder - metabolism Brain - metabolism Child Cytokine Disease Models, Animal Humans Interpersonal Relations Leukocytes, Mononuclear - metabolism Male Mice Microglia Microglia - metabolism Neuregulin Neuregulin-1 - genetics Neuregulin-1 - metabolism Neurons - metabolism PBMCs Psychiatry Social Isolation
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Beschreibung
Zusammenfassung:	Highlights • Neuregulins (NRGs) are expressed in microglia. • Microglial NRG expression is significantly increased in BTBR and socially isolated mice. • NRG1 type III levels in PBMCs are correlated with scores of ADI-R domain A.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2017.01.003