The clinical and prognostic significance of acute myeloid leukemia with FLT3-ITD

To investigate the clinical significance and prognosis factors of acute myeloid leukemia (AML) with FLT3 mutation-internal tandem duplication (FLT3-ITD) and provide more evidence for prognosis evaluation in AML with FLT3-ITD. The clinical characteristics and outcomes of 98 AML with FLT3-ITD were analyzed. In patients with FLT3-ITD positive AML, the median of WBC and peripheral blood blast at initial diagnosis were 58.2 (0.3-461.8) ×10 /L and 42.2 (0-397.1) ×10 /L, respectively. The complete remission (CR) rate after one course induction therapy was 60.6% in 71 patients with intermediate or adverse risk. The primary refractory rate was 26.8% in 71 patients with intermediate or adverse risk. The lower number of peripheral blood blast was a favorable factor to achieve CR after one course induction therapy ( =0.009). CR after one course ( =0.395, 95% 0.183-0.85, =0.001) and allo-transplantation in CR ( =0.180, 95% 0.043-0.752, =0.018) favored longer relapse-free survival (RFS). CR after one course ( =0.251, 95% 0