Tunicamycin impairs olfactory learning and synaptic plasticity in the olfactory bulb

Highlights • Tunicamycin (TM) impairs aversive olfactory learning. • TM upregulates CHOP in the main olfactory bulb (MOB). • TM inhibits synaptic plasticity via presynaptic and postsynaptic mechanisms in MOB.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2017-03, Vol.344, p.371-379
Hauptverfasser:	Tong, Jia, Okutani, Fumino, Murata, Yoshihiro, Taniguchi, Mustuo, Namba, Toshiharu, Wang, Yu-Jie, Kaba, Hideto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals aversive olfactory learning C/EBP homologous protein Dose-Response Relationship, Drug Endoplasmic Reticulum Stress - drug effects Endoplasmic Reticulum Stress - physiology Female Learning - drug effects Learning - physiology Learning Disorders - chemically induced Learning Disorders - pathology Learning Disorders - physiopathology long-term potentiation Long-Term Potentiation - drug effects Long-Term Potentiation - physiology main olfactory bulb Male Neurology Olfactory Bulb - drug effects Olfactory Bulb - pathology Olfactory Bulb - physiopathology Olfactory Perception - drug effects Olfactory Perception - physiology paired-pulse facilitation Presynaptic Terminals - drug effects Presynaptic Terminals - physiology Random Allocation Rats, Long-Evans synaptic plasticity Tissue Culture Techniques Transcription Factor CHOP - metabolism Tunicamycin - toxicity
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Beschreibung
Zusammenfassung:	Highlights • Tunicamycin (TM) impairs aversive olfactory learning. • TM upregulates CHOP in the main olfactory bulb (MOB). • TM inhibits synaptic plasticity via presynaptic and postsynaptic mechanisms in MOB.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2017.01.001