miR424-5p functions as an anti-oncogene in cervical cancer cell growth by targeting KDM5B via the Notch signaling pathway

Aberrant expression of miRNAs exert the critical roles in carcinogenesis, including cervical cancer. Recent study corroborated the down-regulation of miR424-5p in uterine cervix adenocarcinoma. This research aimed to investigate the function and underlying mechanisms of miR424-5p in cervical cancer...

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Veröffentlicht in:	Life sciences (1973) 2017-02, Vol.171, p.9-15
Hauptverfasser:	Zhou, Yan, An, Qi, Guo, Rui-xia, Qiao, Yu-huan, Li, Liu-xia, Zhang, Xiao-yan, Zhao, Xian-lan
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Aberration Adenocarcinoma Apoptosis Cancer Carcinogenesis Carcinogens Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - genetics Cervical cancer Cervical carcinoma Cytometry Female Flow cytometry Gene Knockdown Techniques Genes, Tumor Suppressor Humans Inhibitors Jagged1 Jagged1 protein Jumonji Domain-Containing Histone Demethylases - genetics KDM5B MicroRNAs MicroRNAs - genetics MiR424-5p Notch1 protein Notch2 protein Nuclear Proteins - genetics Oncogenes Receptors, Notch - metabolism Repressor Proteins - genetics Signal Transduction Target recognition Tissues Transfection Uterine cancer Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - pathology Uterus
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