Mitral Regurgitation After Orthotopic Lung Transplantation: Natural History and Impact on Outcomes

Objective Progression of mitral regurgitation (MR) after orthotopic lung transplantation (OLT) may be an underrecognized phenomenon due to the overlapping symptomatology of pulmonary and valvular disease. Literature evaluating the progression of MR after OLT currently is limited to case reports. The...

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Veröffentlicht in:	Journal of cardiothoracic and vascular anesthesia 2017-06, Vol.31 (3), p.924-930
Hauptverfasser:	McCartney, Sharon L., MD, Cooter, Mary, MS, Samad, Zainab, MD, MHS, Sivak, Joseph, MD, Castleberry, Anthony, MD, Gregory, Stephen, MD, Haney, John, MD, Hartwig, Matthew, MD, Swaminathan, Madhav, MD, MB, BS
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anesthesia & Perioperative Care Cohort Studies Critical Care Echocardiography, Transesophageal - trends Female Follow-Up Studies Humans lung transplantation Lung Transplantation - adverse effects Lung Transplantation - trends Male Middle Aged mitral incompetence mitral insufficiency mitral regurgitation mitral valve incompetence mitral valve insufficiency Mitral Valve Insufficiency - diagnostic imaging Mitral Valve Insufficiency - etiology Mitral Valve Insufficiency - mortality mitral valve regurgitation Postoperative Complications - diagnostic imaging Postoperative Complications - etiology Postoperative Complications - mortality Retrospective Studies Survival Rate - trends Treatment Outcome
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Zusammenfassung:	Objective Progression of mitral regurgitation (MR) after orthotopic lung transplantation (OLT) may be an underrecognized phenomenon due to the overlapping symptomatology of pulmonary and valvular disease. Literature evaluating the progression of MR after OLT currently is limited to case reports. Therefore, the hypothesis that MR progresses after OLT was tested and the association of preprocedure MR with postoperative mortality was assessed. Design A retrospective cohort. Setting A tertiary-care hospital. Participants Patients who underwent OLT between January 1, 2003 and February 4, 2012. Interventions After receiving institutional review board approval, a preprocedure transesophageal echocardiogram was compared with a postoperative transthoracic echocardiogram (TTE) to determine the progression of MR. Univariate and multivariate association between preprocedure MR grade and 1- and 5-year mortality was assessed. A p value of
ISSN:	1053-0770 1532-8422
DOI:	10.1053/j.jvca.2016.10.025