Agarose encapsulated mesoporous carbonated hydroxyapatite nanocomposites powder for drug delivery
The powder composites are predominantly used for filling of voids in bone and as drug delivery carrier to prevent the infection or inflammatory reaction in the damaged tissues. The objective of this work was to study the synthesis of agarose encapsulation on carbonated hydroxyapatite powder and thei...
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Veröffentlicht in: | Journal of photochemistry and photobiology. B, Biology Biology, 2017-01, Vol.166, p.220-231 |
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creator | Kolanthai, Elayaraja Abinaya Sindu, P. Thanigai Arul, K. Sarath Chandra, V. Manikandan, E. Narayana Kalkura, S. |
description | The powder composites are predominantly used for filling of voids in bone and as drug delivery carrier to prevent the infection or inflammatory reaction in the damaged tissues. The objective of this work was to study the synthesis of agarose encapsulation on carbonated hydroxyapatite powder and their biological and drug delivery properties. Mesoporous, nanosized carbonated hydroxyapatite/agarose (CHAp/agarose) powder composites were prepared by solvothermal method and subsequently calcined to study the physico-chemical changes, if it subjected to thermal exposure. The phase of the as-synthesized powder was CHAp/agarose whereas the calcinated samples were non-stoichiometric HAp. The CHAp/agarose nanorods were of length 10–80nm and width 40–190nm for the samples synthesized at temperatures 120°C (ST120) and 150°C (ST150). The calcination process produced spheres (10–50nm) and rods with reduced size (40–120nm length and 20–30nm width). Composites were partially dissolved in SBF solution followed by exhibited better bioactivity than non-stoichiometric HAp confirmed by gravimetric method. Hemo and biocompatibility remained unaffected by presence of agarose or carbonate in the HAp. Specific surface area of the composites was high and exhibited an enhanced amoxicillin and 5-fluorouracil release than the calcined samples. The composites demonstrated a strong antimicrobial activity against E. coli, S. aureus and S. epidermidis. The ST120 showed prolonged drug (AMX and 5-Fcil) release and antimicrobial efficacy than ST150 and calcined samples. This technique would be simple and rapid for composites preparation, to produce high quality crystalline, resorbable, mesoporous and bioactive nanocomposite (CHAp/agarose) powders. This work provides new insight into the role of agarose coated on bioceramics by solvothermal technique and suggests that CHAp/agarose composites powders are promising materials for filling of void in bone and drug delivery applications.
[Display omitted]
•Nanosized carbonated hydroxyapatite (CHAp/agarose) powder by solvothermal route•Encapsulation on CHAp powder and bio-medical properties were assessed.•Nanocomposite powders are used for filling of voids in bone materials.•Drug delivery carrier to prevent the infection of the damaged tissues•Nanocomposites exhibit antimicrobial activity of E. coli, S. aureus &S. epidermidis. |
doi_str_mv | 10.1016/j.jphotobiol.2016.12.005 |
format | Article |
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[Display omitted]
•Nanosized carbonated hydroxyapatite (CHAp/agarose) powder by solvothermal route•Encapsulation on CHAp powder and bio-medical properties were assessed.•Nanocomposite powders are used for filling of voids in bone materials.•Drug delivery carrier to prevent the infection of the damaged tissues•Nanocomposites exhibit antimicrobial activity of E. coli, S. aureus &S. epidermidis.</description><identifier>ISSN: 1011-1344</identifier><identifier>EISSN: 1873-2682</identifier><identifier>DOI: 10.1016/j.jphotobiol.2016.12.005</identifier><identifier>PMID: 28012416</identifier><language>eng</language><publisher>Switzerland: Elsevier B.V</publisher><subject>5-Fluorouracil ; 5-fluorouracil and drug delivery ; Amoxcillin ; Amoxicillin ; Antiinfectives and antibacterials ; Antimicrobial activity ; Bioceramics ; Biocompatibility ; Biocompatible Materials ; Biological activity ; Biological properties ; Biomedical materials ; Carbonates - chemistry ; Carbonation ; Cell Line ; Damage prevention ; Drug delivery ; Drug Delivery Systems ; Durapatite - chemistry ; E coli ; Encapsulation ; Gravimetry ; Humans ; Hydroxyapatite ; Inflammation ; Mesoporous ; Nanocomposites ; Nanocomposites - chemistry ; Nanorods ; Nanoscience ; Nanotechnology ; Particulate composites ; Powder ; Powders ; Roasting ; Rods ; Sepharose - chemistry ; Solvothermal ; Spectroscopy, Fourier Transform Infrared ; Spectrum Analysis, Raman ; Surgical implants ; Synthesis ; Thermogravimetry ; Tissues ; X-Ray Diffraction</subject><ispartof>Journal of photochemistry and photobiology. B, Biology, 2017-01, Vol.166, p.220-231</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Jan 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-38ba3d23662173c1bcc5b025a57845a1e233644b515f465c9e55a9ee714b64e73</citedby><cites>FETCH-LOGICAL-c402t-38ba3d23662173c1bcc5b025a57845a1e233644b515f465c9e55a9ee714b64e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jphotobiol.2016.12.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28012416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kolanthai, Elayaraja</creatorcontrib><creatorcontrib>Abinaya Sindu, P.</creatorcontrib><creatorcontrib>Thanigai Arul, K.</creatorcontrib><creatorcontrib>Sarath Chandra, V.</creatorcontrib><creatorcontrib>Manikandan, E.</creatorcontrib><creatorcontrib>Narayana Kalkura, S.</creatorcontrib><title>Agarose encapsulated mesoporous carbonated hydroxyapatite nanocomposites powder for drug delivery</title><title>Journal of photochemistry and photobiology. B, Biology</title><addtitle>J Photochem Photobiol B</addtitle><description>The powder composites are predominantly used for filling of voids in bone and as drug delivery carrier to prevent the infection or inflammatory reaction in the damaged tissues. The objective of this work was to study the synthesis of agarose encapsulation on carbonated hydroxyapatite powder and their biological and drug delivery properties. Mesoporous, nanosized carbonated hydroxyapatite/agarose (CHAp/agarose) powder composites were prepared by solvothermal method and subsequently calcined to study the physico-chemical changes, if it subjected to thermal exposure. The phase of the as-synthesized powder was CHAp/agarose whereas the calcinated samples were non-stoichiometric HAp. The CHAp/agarose nanorods were of length 10–80nm and width 40–190nm for the samples synthesized at temperatures 120°C (ST120) and 150°C (ST150). The calcination process produced spheres (10–50nm) and rods with reduced size (40–120nm length and 20–30nm width). Composites were partially dissolved in SBF solution followed by exhibited better bioactivity than non-stoichiometric HAp confirmed by gravimetric method. Hemo and biocompatibility remained unaffected by presence of agarose or carbonate in the HAp. Specific surface area of the composites was high and exhibited an enhanced amoxicillin and 5-fluorouracil release than the calcined samples. The composites demonstrated a strong antimicrobial activity against E. coli, S. aureus and S. epidermidis. The ST120 showed prolonged drug (AMX and 5-Fcil) release and antimicrobial efficacy than ST150 and calcined samples. This technique would be simple and rapid for composites preparation, to produce high quality crystalline, resorbable, mesoporous and bioactive nanocomposite (CHAp/agarose) powders. This work provides new insight into the role of agarose coated on bioceramics by solvothermal technique and suggests that CHAp/agarose composites powders are promising materials for filling of void in bone and drug delivery applications.
[Display omitted]
•Nanosized carbonated hydroxyapatite (CHAp/agarose) powder by solvothermal route•Encapsulation on CHAp powder and bio-medical properties were assessed.•Nanocomposite powders are used for filling of voids in bone materials.•Drug delivery carrier to prevent the infection of the damaged tissues•Nanocomposites exhibit antimicrobial activity of E. coli, S. aureus &S. epidermidis.</description><subject>5-Fluorouracil</subject><subject>5-fluorouracil and drug delivery</subject><subject>Amoxcillin</subject><subject>Amoxicillin</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial activity</subject><subject>Bioceramics</subject><subject>Biocompatibility</subject><subject>Biocompatible Materials</subject><subject>Biological activity</subject><subject>Biological properties</subject><subject>Biomedical materials</subject><subject>Carbonates - chemistry</subject><subject>Carbonation</subject><subject>Cell Line</subject><subject>Damage prevention</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems</subject><subject>Durapatite - chemistry</subject><subject>E coli</subject><subject>Encapsulation</subject><subject>Gravimetry</subject><subject>Humans</subject><subject>Hydroxyapatite</subject><subject>Inflammation</subject><subject>Mesoporous</subject><subject>Nanocomposites</subject><subject>Nanocomposites - chemistry</subject><subject>Nanorods</subject><subject>Nanoscience</subject><subject>Nanotechnology</subject><subject>Particulate composites</subject><subject>Powder</subject><subject>Powders</subject><subject>Roasting</subject><subject>Rods</subject><subject>Sepharose - chemistry</subject><subject>Solvothermal</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Spectrum Analysis, Raman</subject><subject>Surgical implants</subject><subject>Synthesis</subject><subject>Thermogravimetry</subject><subject>Tissues</subject><subject>X-Ray Diffraction</subject><issn>1011-1344</issn><issn>1873-2682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1TAQhi0Eohd4BWSJDZsEj29JlqWiF6kSG7q2HHtO6yiJg50UztvX7SkgscEL2zP6xjP-f0IosBoY6M9DPSz3cY19iGPNS6YGXjOmXpFjaBtRcd3y1-XOACoQUh6Rk5wHVpbSzVtyxFsGXII-JvbszqaYkeLs7JK30a7o6YQ5LjHFLVNnUx_n5-z93qf4a28Xu4YV6Wzn6OK0xFyiTJf402Oiu5ioT9sd9TiGB0z7d-TNzo4Z37-cp-T24uv386vq5tvl9fnZTeUk42sl2t4Kz4XWHBrhoHdO9Ywrq5pWKgvIhdBS9grUTmrlOlTKdogNyF5LbMQp-XR4d0nxx4Z5NVPIDsfRzlg-YqBVXaNk18qCfvwHHeKW5jKdgU5oVTYBhWoPlCsC5YQ7s6Qw2bQ3wMyTDWYwf20wTzYY4KZoXEo_vDTY-gn9n8LfuhfgywHAoshDwGSyC8UC9CGhW42P4f9dHgE9_J98</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Kolanthai, Elayaraja</creator><creator>Abinaya Sindu, P.</creator><creator>Thanigai Arul, K.</creator><creator>Sarath Chandra, V.</creator><creator>Manikandan, E.</creator><creator>Narayana Kalkura, S.</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>201701</creationdate><title>Agarose encapsulated mesoporous carbonated hydroxyapatite nanocomposites powder for drug delivery</title><author>Kolanthai, Elayaraja ; Abinaya Sindu, P. ; Thanigai Arul, K. ; Sarath Chandra, V. ; Manikandan, E. ; Narayana Kalkura, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-38ba3d23662173c1bcc5b025a57845a1e233644b515f465c9e55a9ee714b64e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>5-Fluorouracil</topic><topic>5-fluorouracil and drug delivery</topic><topic>Amoxcillin</topic><topic>Amoxicillin</topic><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial activity</topic><topic>Bioceramics</topic><topic>Biocompatibility</topic><topic>Biocompatible Materials</topic><topic>Biological activity</topic><topic>Biological properties</topic><topic>Biomedical materials</topic><topic>Carbonates - chemistry</topic><topic>Carbonation</topic><topic>Cell Line</topic><topic>Damage prevention</topic><topic>Drug delivery</topic><topic>Drug Delivery Systems</topic><topic>Durapatite - chemistry</topic><topic>E coli</topic><topic>Encapsulation</topic><topic>Gravimetry</topic><topic>Humans</topic><topic>Hydroxyapatite</topic><topic>Inflammation</topic><topic>Mesoporous</topic><topic>Nanocomposites</topic><topic>Nanocomposites - chemistry</topic><topic>Nanorods</topic><topic>Nanoscience</topic><topic>Nanotechnology</topic><topic>Particulate composites</topic><topic>Powder</topic><topic>Powders</topic><topic>Roasting</topic><topic>Rods</topic><topic>Sepharose - chemistry</topic><topic>Solvothermal</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Spectrum Analysis, Raman</topic><topic>Surgical implants</topic><topic>Synthesis</topic><topic>Thermogravimetry</topic><topic>Tissues</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kolanthai, Elayaraja</creatorcontrib><creatorcontrib>Abinaya Sindu, P.</creatorcontrib><creatorcontrib>Thanigai Arul, K.</creatorcontrib><creatorcontrib>Sarath Chandra, V.</creatorcontrib><creatorcontrib>Manikandan, E.</creatorcontrib><creatorcontrib>Narayana Kalkura, S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of photochemistry and photobiology. B, Biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kolanthai, Elayaraja</au><au>Abinaya Sindu, P.</au><au>Thanigai Arul, K.</au><au>Sarath Chandra, V.</au><au>Manikandan, E.</au><au>Narayana Kalkura, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Agarose encapsulated mesoporous carbonated hydroxyapatite nanocomposites powder for drug delivery</atitle><jtitle>Journal of photochemistry and photobiology. B, Biology</jtitle><addtitle>J Photochem Photobiol B</addtitle><date>2017-01</date><risdate>2017</risdate><volume>166</volume><spage>220</spage><epage>231</epage><pages>220-231</pages><issn>1011-1344</issn><eissn>1873-2682</eissn><abstract>The powder composites are predominantly used for filling of voids in bone and as drug delivery carrier to prevent the infection or inflammatory reaction in the damaged tissues. The objective of this work was to study the synthesis of agarose encapsulation on carbonated hydroxyapatite powder and their biological and drug delivery properties. Mesoporous, nanosized carbonated hydroxyapatite/agarose (CHAp/agarose) powder composites were prepared by solvothermal method and subsequently calcined to study the physico-chemical changes, if it subjected to thermal exposure. The phase of the as-synthesized powder was CHAp/agarose whereas the calcinated samples were non-stoichiometric HAp. The CHAp/agarose nanorods were of length 10–80nm and width 40–190nm for the samples synthesized at temperatures 120°C (ST120) and 150°C (ST150). The calcination process produced spheres (10–50nm) and rods with reduced size (40–120nm length and 20–30nm width). Composites were partially dissolved in SBF solution followed by exhibited better bioactivity than non-stoichiometric HAp confirmed by gravimetric method. Hemo and biocompatibility remained unaffected by presence of agarose or carbonate in the HAp. Specific surface area of the composites was high and exhibited an enhanced amoxicillin and 5-fluorouracil release than the calcined samples. The composites demonstrated a strong antimicrobial activity against E. coli, S. aureus and S. epidermidis. The ST120 showed prolonged drug (AMX and 5-Fcil) release and antimicrobial efficacy than ST150 and calcined samples. This technique would be simple and rapid for composites preparation, to produce high quality crystalline, resorbable, mesoporous and bioactive nanocomposite (CHAp/agarose) powders. This work provides new insight into the role of agarose coated on bioceramics by solvothermal technique and suggests that CHAp/agarose composites powders are promising materials for filling of void in bone and drug delivery applications.
[Display omitted]
•Nanosized carbonated hydroxyapatite (CHAp/agarose) powder by solvothermal route•Encapsulation on CHAp powder and bio-medical properties were assessed.•Nanocomposite powders are used for filling of voids in bone materials.•Drug delivery carrier to prevent the infection of the damaged tissues•Nanocomposites exhibit antimicrobial activity of E. coli, S. aureus &S. epidermidis.</abstract><cop>Switzerland</cop><pub>Elsevier B.V</pub><pmid>28012416</pmid><doi>10.1016/j.jphotobiol.2016.12.005</doi><tpages>12</tpages></addata></record> |
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subjects | 5-Fluorouracil 5-fluorouracil and drug delivery Amoxcillin Amoxicillin Antiinfectives and antibacterials Antimicrobial activity Bioceramics Biocompatibility Biocompatible Materials Biological activity Biological properties Biomedical materials Carbonates - chemistry Carbonation Cell Line Damage prevention Drug delivery Drug Delivery Systems Durapatite - chemistry E coli Encapsulation Gravimetry Humans Hydroxyapatite Inflammation Mesoporous Nanocomposites Nanocomposites - chemistry Nanorods Nanoscience Nanotechnology Particulate composites Powder Powders Roasting Rods Sepharose - chemistry Solvothermal Spectroscopy, Fourier Transform Infrared Spectrum Analysis, Raman Surgical implants Synthesis Thermogravimetry Tissues X-Ray Diffraction |
title | Agarose encapsulated mesoporous carbonated hydroxyapatite nanocomposites powder for drug delivery |
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