Correlation of whole kidney hypertrophy with glomerular over‐filtration in live, gender‐mismatched renal transplant allografts

ABSTRACT Aim Optimizing nephron supply to recipient demand is a non‐immunologic determinant of renal allograft outcome. Nephron reduction is usually caused by physical donor‐recipient mismatch, but its pathologic relevance remains to be determined. Methods Thirty‐one recipients of living donor renal transplants were divided into three subgroups: those who received transplants from the same gender (n = 6, Group 1) and those who underwent male‐to‐female (n = 8, Group 2) and female‐to‐male (n = 17, Group 3) transplants. Renal mass was evaluated by three‐dimensional computed tomography (3D‐CT) volumetry before and one year after transplantation. Glomerular volume was determined from protocol biopsies obtained one hour and one year after transplantation. Results Histologically determined glomerular volume in biopsied tissues showed a significant linear correlation with allograft size on 3D‐CT volumetry (P