Editorial commentary: Targeting Chagas disease

Upregulation of these mediators may also be regarded as a "double-edged sword," in that these mediators are involved in causing myocardial depression [3]. Besides CCD, other cardiac diseases, for example, heart failure, cardiac reperfusion injury, myocardial infarction, and sepsis-induced cardiac dysfunction are also associated with inflammatory cytokine activation. [...]infliximab therapy, which blocks TNF activity, has been found to reduce myocardial pathology in T. cruzi-infected rodents [8].