Rapid infectious disease identification by next-generation DNA sequencing

Currently, there is a critical need to rapidly identify infectious organisms in clinical samples. Next-Generation Sequencing (NGS) could surmount the deficiencies of culture-based methods; however, there are no standardized, automated programs to process NGS data. To address this deficiency, we deve...

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Veröffentlicht in:	Journal of microbiological methods 2017-07, Vol.138, p.12-19
Hauptverfasser:	Ellis, Jeremy E., Missan, Dara S., Shabilla, Matthew, Martinez, Delyn, Fry, Stephen E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria - classification Bacteria - genetics Clinical NGS Communicable Diseases - diagnosis Community profiling Diagnosis, Computer-Assisted DNA - analysis High-Throughput Nucleotide Sequencing - methods Humans Limit of Detection Next generation DNA sequencing NGS validation Rapid infectious disease identification RNA, Ribosomal, 16S - genetics Sequence Analysis, DNA - methods
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