Effect of Bilateral Prefrontal rTMS on Left Prefrontal NAA and Glx Levels in Schizophrenia Patients with Predominant Negative Symptoms: an Exploratory Study

Highlights • We studied neurotransmitters concentrations changes in the left prefrontal cortex of patients with schizophrenia after bilateral prefrontal high frequency rTMS • An increase of glutamate concentration was found after active rTMS, a decrease after sham rTMS • Prefrontal rTMS did not infl...

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Veröffentlicht in:	Brain stimulation 2017-01, Vol.10 (1), p.59-64
Hauptverfasser:	Dlabac-de Lange, Jozarni J., MD, PhD, Liemburg, Edith J., PhD, Bais, Leonie, MSc, van de Poel-Mustafayeva, Aida T, de Lange-de Klerk, E.S.M., MD, PhD, Knegtering, Henderikus, MD, PhD, Aleman, André, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	1H-Magnetic resonance spectroscopy Adult Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Dorsolateral prefrontal cortex Double-Blind Method Female Glutamate Glutamic Acid - metabolism Humans Magnetic Resonance Imaging - methods Male Middle Aged N-Acetyl aspartate Negative symptoms Neurology Pessimism Prefrontal Cortex - metabolism Randomized controlled trial Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - metabolism Schizophrenia - therapy Transcranial magnetic stimulation Transcranial Magnetic Stimulation - methods Treatment Outcome Young Adult
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Zusammenfassung:	Highlights • We studied neurotransmitters concentrations changes in the left prefrontal cortex of patients with schizophrenia after bilateral prefrontal high frequency rTMS • An increase of glutamate concentration was found after active rTMS, a decrease after sham rTMS • Prefrontal rTMS did not influence N-Acetyl Aspartate concentration • High frequency prefrontal rTMS may increase prefrontal metabolism in patients with schizophrenia
ISSN:	1935-861X 1876-4754
DOI:	10.1016/j.brs.2016.08.002