Nicotinamide-independent asymmetric bioreduction of C=C-bonds via disproportionation of enones catalyzed by enoate reductases

The asymmetric bioreduction of activated C-C-bonds catalyzed by a single flavoprotein was achieved via direct hydrogen transfer from a sacrificial 2-enone or 1,4-dione as hydrogen donor without requirement of a nicotinamide cofactor. Due to its simplicity, this system has clear advantages over conve...

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Veröffentlicht in:	Tetrahedron 2010-01, Vol.66 (3), p.663-667
Hauptverfasser:	STUECKLER, Clemens, REITER, Tamara C, BAUDENDISTEL, Nina, FABER, Kurt
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Chemistry Exact sciences and technology Fundamental and applied biological sciences. Psychology Kinetics and mechanisms Methods. Procedures. Technologies Organic chemistry Reactivity and mechanisms
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Beschreibung
Zusammenfassung:	The asymmetric bioreduction of activated C-C-bonds catalyzed by a single flavoprotein was achieved via direct hydrogen transfer from a sacrificial 2-enone or 1,4-dione as hydrogen donor without requirement of a nicotinamide cofactor. Due to its simplicity, this system has clear advantages over conventional FAD-recycling systems.
ISSN:	0040-4020 1464-5416
DOI:	10.1016/j.tet.2009.11.065