Toll-like receptor 4-dependent glial cell activation mediates the impairment in memory establishment induced by β-amyloid oligomers in an acute mouse model of Alzheimer’s disease

Highlights • An ICV injection of AβO impairing memory leads also to a rapid glial activation. • Anti-inflammatory drugs prevent the AβO-mediated memory impairment. • AβO-mediated effects are abolished by TLR4 antagonist or in TLR4-/- mice. • Concluding, TLR4-mediated glial activation is involved in...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2017-02, Vol.60, p.188-197
Hauptverfasser:	Balducci, Claudia, Frasca, Angelisa, Zotti, Margherita, La Vitola, Pietro, Mhillaj, Emanuela, Grigoli, Emanuele, Iacobellis, Martina, Grandi, Federica, Messa, Massimo, Colombo, Laura, Molteni, Monica, Trabace, Luigia, Rossetti, Carlo, Salmona, Mario, Forloni, Gianluigi
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Alzheimer’s disease Beta-amyloid oligomers IL-1β IL-1β receptor antagonist Indomethacin Memory impairment Neuroinflammation Novel object recognition test Pro-inflammatory cytokines Psychiatry Toll-like receptor 4
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Zusammenfassung:	Highlights • An ICV injection of AβO impairing memory leads also to a rapid glial activation. • Anti-inflammatory drugs prevent the AβO-mediated memory impairment. • AβO-mediated effects are abolished by TLR4 antagonist or in TLR4-/- mice. • Concluding, TLR4-mediated glial activation is involved in AβO-induced memory impairment.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.10.012