Statins prevent cognitive impairment after sepsis by reverting neuroinflammation, and microcirculatory/endothelial dysfunction
Highlights • Sepsis induces neuroinflammation, endothelial dysfunction and cognitive decline in mice; • Statins prevent cognitive impairment after sepsis independent of changes in survival; • Statins treatment modulate neuroinflammation after septic challenge; • Statins protect brain microcirculatio...
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| Veröffentlicht in: | Brain, behavior, and immunity behavior, and immunity, 2017-02, Vol.60, p.293-303 |
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| container_title | Brain, behavior, and immunity |
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| creator | Reis, Patricia A Alexandre, Pedro C.B D’Avila, Joana C Siqueira, Luciana D Antunes, Barbara Estato, Vanessa Tibiriça, Eduardo V Verdonk, Franck Sharshar, Tarek Chrétien, Fabrice Castro-Faria-Neto, Hugo C Bozza, Fernando A |
| description | Highlights • Sepsis induces neuroinflammation, endothelial dysfunction and cognitive decline in mice; • Statins prevent cognitive impairment after sepsis independent of changes in survival; • Statins treatment modulate neuroinflammation after septic challenge; • Statins protect brain microcirculation during sepsis. |
| doi_str_mv | 10.1016/j.bbi.2016.11.006 |
| format | Article |
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| ispartof | Brain, behavior, and immunity, 2017-02, Vol.60, p.293-303 |
| issn | 0889-1591 1090-2139 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Allergy and Immunology Cognition Endothelium Neuroinflammation Psychiatry Sepsis Statin |
| title | Statins prevent cognitive impairment after sepsis by reverting neuroinflammation, and microcirculatory/endothelial dysfunction |
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