Statins prevent cognitive impairment after sepsis by reverting neuroinflammation, and microcirculatory/endothelial dysfunction

Statins prevent cognitive impairment after sepsis by reverting neuroinflammation, and microcirculatory/endothelial dysfunction

Highlights • Sepsis induces neuroinflammation, endothelial dysfunction and cognitive decline in mice; • Statins prevent cognitive impairment after sepsis independent of changes in survival; • Statins treatment modulate neuroinflammation after septic challenge; • Statins protect brain microcirculatio...

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Veröffentlicht in:Brain, behavior, and immunity behavior, and immunity, 2017-02, Vol.60, p.293-303
Hauptverfasser: Reis, Patricia A, Alexandre, Pedro C.B, D’Avila, Joana C, Siqueira, Luciana D, Antunes, Barbara, Estato, Vanessa, Tibiriça, Eduardo V, Verdonk, Franck, Sharshar, Tarek, Chrétien, Fabrice, Castro-Faria-Neto, Hugo C, Bozza, Fernando A
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Cognition
Endothelium
Neuroinflammation
Psychiatry
Sepsis
Statin
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Zusammenfassung:Highlights • Sepsis induces neuroinflammation, endothelial dysfunction and cognitive decline in mice; • Statins prevent cognitive impairment after sepsis independent of changes in survival; • Statins treatment modulate neuroinflammation after septic challenge; • Statins protect brain microcirculation during sepsis.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.11.006