Human albumin attenuates excessive innate immunity via inhibition of microglial Mincle/Syk signaling in subarachnoid hemorrhage

Human albumin attenuates excessive innate immunity via inhibition of microglial Mincle/Syk signaling in subarachnoid hemorrhage

Highlights • Subarachnoid hemorrhage activates cerebral innate immunity by Mincle/Syk pathway. • Albumin can abolish immune responses by directly binding microglial Mincle receptor after subarachnoid hemorrhage. • Neuronal necroptosis product, SAP130, launches the stimulation of Mincle on microglial...

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Veröffentlicht in:Brain, behavior, and immunity behavior, and immunity, 2017-02, Vol.60, p.346-360
Hauptverfasser: Xie, Yi, Guo, Hongquan, Wang, Liumin, Xu, Lili, Zhang, Xiaohao, Yu, Linjie, Liu, Qian, Li, Yunzi, Zhao, Nana, Zhao, Nan, Ye, Ruidong, Liu, Xinfeng
Format: Artikel
Sprache:eng
Schlagworte:
Albumin
Allergy and Immunology
Microglia
Mincle
Psychiatry
Subarachnoid hemorrhage
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Zusammenfassung:Highlights • Subarachnoid hemorrhage activates cerebral innate immunity by Mincle/Syk pathway. • Albumin can abolish immune responses by directly binding microglial Mincle receptor after subarachnoid hemorrhage. • Neuronal necroptosis product, SAP130, launches the stimulation of Mincle on microglial cells. • Albumin supplementation can deactivate SAP130-induced microglial motivation.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.11.004