Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe?
Highlights • Chronic stress triggers loss of dopaminergic neurons within the substantia nigra. • Increased level of oxidative stress. • Suppressed glia neuroprotective functions. • Enhanced the aggregation of α-synuclein.
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| Veröffentlicht in: | Brain, behavior, and immunity behavior, and immunity, 2017-02, Vol.60, p.117-125 |
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| container_title | Brain, behavior, and immunity |
| container_volume | 60 |
| creator | Ong, Lin Kooi Zhao, Zidan Kluge, Murielle TeBay, Clifford Zalewska, Katarzyna Dickson, Phillip W Johnson, Sarah J Nilsson, Michael Walker, Frederick R |
| description | Highlights • Chronic stress triggers loss of dopaminergic neurons within the substantia nigra. • Increased level of oxidative stress. • Suppressed glia neuroprotective functions. • Enhanced the aggregation of α-synuclein. |
| doi_str_mv | 10.1016/j.bbi.2016.10.001 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0889-1591 |
| ispartof | Brain, behavior, and immunity, 2017-02, Vol.60, p.117-125 |
| issn | 0889-1591 1090-2139 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Allergy and Immunology Astrocytes Chronic stress Microglia Neurodegeneration Oxidative stress Psychiatry Substantia nigra α-Synuclein |
| title | Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe? |
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