Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe?

Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe?

Highlights • Chronic stress triggers loss of dopaminergic neurons within the substantia nigra. • Increased level of oxidative stress. • Suppressed glia neuroprotective functions. • Enhanced the aggregation of α-synuclein.

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Bibliographische Detailangaben
Veröffentlicht in:Brain, behavior, and immunity behavior, and immunity, 2017-02, Vol.60, p.117-125
Hauptverfasser: Ong, Lin Kooi, Zhao, Zidan, Kluge, Murielle, TeBay, Clifford, Zalewska, Katarzyna, Dickson, Phillip W, Johnson, Sarah J, Nilsson, Michael, Walker, Frederick R
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Astrocytes
Chronic stress
Microglia
Neurodegeneration
Oxidative stress
Psychiatry
Substantia nigra
α-Synuclein
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Beschreibung
Zusammenfassung:Highlights • Chronic stress triggers loss of dopaminergic neurons within the substantia nigra. • Increased level of oxidative stress. • Suppressed glia neuroprotective functions. • Enhanced the aggregation of α-synuclein.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.10.001