Intravenous injection of gadobutrol in an epidemiological study group did not lead to a difference in relative signal intensities of certain brain structures after 5 years

Purpose To investigate if application of macrocyclic gadolinium-based contrast agents in volunteers is associated with neuronal deposition detected by magnetic resonance imaging in a 5-year longitudinal survey. Materials and methods Three hundred eighty-seven volunteers who participated in a populat...

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Veröffentlicht in:European radiology 2017-02, Vol.27 (2), p.772-777
Hauptverfasser: Kromrey, Marie-Luise, Liedtke, Kim Rouven, Ittermann, Till, Langner, Sönke, Kirsch, Michael, Weitschies, Werner, Kühn, Jens-Peter
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Sprache:eng
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Zusammenfassung:Purpose To investigate if application of macrocyclic gadolinium-based contrast agents in volunteers is associated with neuronal deposition detected by magnetic resonance imaging in a 5-year longitudinal survey. Materials and methods Three hundred eighty-seven volunteers who participated in a population-based study were enrolled. Subjects underwent plain T1-weighted brain MRI at baseline and 5 years later with identical sequence parameters. At baseline, 271 participants additionally received intravenous injection of the macrocyclic contrast agent gadobutrol (1.5 mmol/kg). A control group including 116 subjects received no contrast agent. Relative signal intensities of thalamus, pallidum, pons and dentate nucleus were compared at baseline and follow-up. Results No difference in relative signal intensities was observed between contrast group (thalamus, p = 0.865; pallidum, p = 0.263; pons, p = 0.533; dentate nucleus, p = 0.396) and control group (thalamus, p = 0.683; pallidum; p = 0.970; pons, p = 0.773; dentate nucleus, p = 0.232) at both times. Comparison between both groups revealed no significant differences in relative signal intensities (thalamus, p = 0.413; pallidum, p = 0.653; pons, p = 0.460; dentate nucleus, p = 0.751). The study showed no significant change in globus pallidus-to-thalamus or dentate nucleus-to-pons ratios. Conclusions Five years after administration of a 1.5-fold dose gadobutrol to normal subjects, signal intensity of thalamus, pallidum, pons and dentate nucleus did not differ from participants who had not received gadobutrol. Key Points • Gadobutrol does not lead to neuronal signal alterations after 5 years . • Neuronal deposition of macrocyclic contrast agent could not be confirmed . • Macrocyclic contrast agents in a proven dosage are safe .
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-016-4418-z