Trigger and Signal Mechanisms and the End Effector of the Cardioprotective Effect of Remote Postconditioning of the Heart

Trigger and Signal Mechanisms and the End Effector of the Cardioprotective Effect of Remote Postconditioning of the Heart

High molecular weight peptide(s) operate as the trigger for remote postconditioning (RPC) of the heart. Nitric oxide and adenosine function as mediators between peptide and intracellular structures. The autonomic nervous system does not have a role in RPC. The signal mechanism of RPC involves protei...

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Veröffentlicht in:Neuroscience and behavioral physiology 2017-02, Vol.47 (2), p.186-189
Hauptverfasser: Maslov, L. N., Mukhomedzyanov, A. V., Sementsov, A. S.
Format: Artikel
Sprache:eng
Schlagworte:
1-Phosphatidylinositol 3-kinase
Adenosine
AKT protein
Aldehyde dehydrogenase
Autonomic nervous system
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Dehydrogenase
Heart
Intracellular
Kinases
Molecular weight
Neurobiology
Neurosciences
Nitric oxide
Protein kinase
Protein kinase C
Xenografts
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Zusammenfassung:High molecular weight peptide(s) operate as the trigger for remote postconditioning (RPC) of the heart. Nitric oxide and adenosine function as mediators between peptide and intracellular structures. The autonomic nervous system does not have a role in RPC. The signal mechanism of RPC involves protein kinase C, PI3 kinase, Akt kinase, and aldehyde dehydrogenase. The hypothetical end effector of RPC is the BK Ca channel
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-016-0384-9