Disease Activity As a Major Determinant of Quality of Life and Physical Function in Patients With Early Axial Spondyloarthritis

Objective To describe health‐related quality of life (HRQOL) and physical function in patients with early axial spondyloarthritis (SpA) and to assess their associations with disease activity and radiographic damage. Methods This was a cross‐sectional study drawing upon baseline data of axial SpA pat...

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Veröffentlicht in:	Arthritis care & research (2010) 2017-01, Vol.69 (1), p.150-155
Hauptverfasser:	Fernández‐Carballido, Cristina, Navarro‐Compán, Victoria, Castillo‐Gallego, Concepción, Castro‐Villegas, Maria C., Collantes‐Estévez, Eduardo, de Miguel, Eugenio, Collantes, E., Reina Sofía, H., Carmona, L., Gobbo, M., Mulero, J., Puerta de Hierro, H., Muñoz‐Fernández, S., Infanta Sofía, H., Zarco, P., Alcorcón, F. H., Rivera, J., Gregorio Marañón, H., López Robledillo, J. C., Niño Jesús, H., Castillo Gallego, C., La Paz, H. U., Rosas, J., Santos, G., Marina Baixa, H., Fernández Sueiro, J. L., Pinto Tasende, J., González Díaz de Rabago, E., Juanv, H. U., Montilla, C., Gómez Castro López, S., del Pino Montes, R. J., de Salamanca, H. U., Granados Bautista, I. P., Hernández Sanz, A., Virgen de la Salud, H., Sanz Sanz, J., Fernández Prada, M., Tornero, J., de Guadalajara, H. U., Campos, C., Calvo, J., de Valencia, H. G. U., Juanola, X., Ríos, V., de Bellvitge, H. U., Moreno, E., Rotés, M. I., de San Rafael, H., Ibero, I., Jovaní, V., Martínez Alberola, N., de Elda, H. G. U., Linares, L. F., Moreno Ramos, M. J., Uceda, A., Moreno Martínez, M. J., Beteta, M. D., Virgen de la Arrixaca, H. U., Quevedo, J. C., Rodríguez Lozano, C., Negrín, H. U., Trujillo, E., Bustabad, S., de Canarias, H. U., Román Ivorra, J. A., Muñoz Gil, S., Peset, H. U., Juan Mas, A., Ros Vilamajó, I., Ibáñez Barceló, M., Son Llatzer, H., Gratacós Matmija, J., Moreno Martínez‐Loza, M., Sabadell, H., Almodóvar, R., Fundación Alcorcón, H., Rejón, E., Rodríguez Montero, S., Virgen de Valme, H. U., Ruiz Jimeno, T., Sierrallana, H., Aznar, J. J., Chamizo Carmona, E., Garrido Puñal, N., de Mérida, H., Fernández Dapica, P., Brito Brito, E., Ramón y Cajal, H., Pérez Pampín, E., Clínico, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Ankylosing spondylitis Arthritis Back pain C-reactive protein Cross-Sectional Studies Female Health risk assessment Humans Inflammatory diseases Male Mobility Multivariate analysis Pain Quality of Life Rheumatic diseases Spine Spondylarthritis - physiopathology Spondylitis Visual perception
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Zusammenfassung:	Objective To describe health‐related quality of life (HRQOL) and physical function in patients with early axial spondyloarthritis (SpA) and to assess their associations with disease activity and radiographic damage. Methods This was a cross‐sectional study drawing upon baseline data of axial SpA patients (Assessment of SpondyloArthritis international Society criteria) from the ESPERANZA cohort. Linear regression analyses were used to evaluate the associations between disease activity and radiographic damage (spine and sacroiliac joints) with HRQOL, physical function, and spinal mobility. Results In total, 259 patients were included. The mean ± SD age was 32.2 ± 6.9 years, disease duration was 13.3 ± 6.8 months, Ankylosing Spondylitis Quality of Life score was 5.9 ± 4.8, Bath Ankylosing Spondylitis Functional Index score was 2.4 ± 2.3, Bath Ankylosing Spondylitis Metrology Index score was 1.4 ± 1.3, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score was 3.8 ± 2.3, C‐reactive protein (CRP) level was 9.7 ± 13.2 mg/liter, and Bath Ankylosing Spondylitis Radiology Index for the spine (BASRI‐s) score was 1.7 ± 1.6. HRQOL was mainly associated with disease activity on univariate analysis (β values for BASDAI 0.646, patient global visual analog scale [VAS] 0.641, night back pain VAS 0.598, physician VAS 0.560, and CRP level 0.275; P
ISSN:	2151-464X 2151-4658
DOI:	10.1002/acr.22908