The expression of chemorepulsive guidance receptors and the regenerative abilities of spinal-projecting neurons after spinal cord injury

Highlights • Neogenin is preferentially expressed in the low regeneration capacity neurons. • Downregulation of Neogenin enhances the axonal regeneration after SCI. • Lamprey neurons co-express multiple receptors (Neogenin, UNC5 and PlexinA) • The regeneration depends on co-expression of chemorepuls...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2017-01, Vol.341, p.95-111
Hauptverfasser:	Chen, Jie, Laramore, Cindy, Shifman, Michael I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals axon guidance Axons - metabolism Axons - pathology Blotting, Western Cell Count Chemotaxis - physiology Disease Models, Animal Down-Regulation Fish Proteins - antagonists & inhibitors Fish Proteins - genetics Fish Proteins - metabolism identifiable neurons In Situ Hybridization In Situ Nick-End Labeling lamprey Lampreys Mauthner cell Membrane Proteins - antagonists & inhibitors Membrane Proteins - genetics Membrane Proteins - metabolism mRNA expression Nerve Tissue Proteins - antagonists & inhibitors Nerve Tissue Proteins - metabolism Neuroanatomical Tract-Tracing Techniques Neurology Oligonucleotides, Antisense Petromyzontidae RNA, Messenger - metabolism Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology spinal cord regeneration Spinal Cord Regeneration - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Neogenin is preferentially expressed in the low regeneration capacity neurons. • Downregulation of Neogenin enhances the axonal regeneration after SCI. • Lamprey neurons co-express multiple receptors (Neogenin, UNC5 and PlexinA) • The regeneration depends on co-expression of chemorepulsive guidance receptors.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.11.020