Sifting through CD8+ T Cell Memory

In this issue of Immunity, Gerlach et al. (2016) describe three distinct memory CD8+ T cell subsets based upon expression of the fractalkine receptor CX3CR1. Their findings revise the paradigm of effector and central memory T cells by revealing a subset of CD8+ memory T cells defined by intermediate...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2016-12, Vol.45 (6), p.1184-1186
Hauptverfasser:	Martin, Matthew D., Badovinac, Vladimir P.
Format:	Artikel
Sprache:	eng
Schlagworte:	CD8-Positive T-Lymphocytes - immunology Cytotoxicity Genotype & phenotype Immunologic Memory - immunology Infections Lymphatic system Lymphocytes Pathogens Researchers Surveillance T cell receptors T-Lymphocyte Subsets - immunology
Online-Zugang:	Volltext
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Zusammenfassung:	In this issue of Immunity, Gerlach et al. (2016) describe three distinct memory CD8+ T cell subsets based upon expression of the fractalkine receptor CX3CR1. Their findings revise the paradigm of effector and central memory T cells by revealing a subset of CD8+ memory T cells defined by intermediate levels of expression of CX3CR1 that conducts tissue surveillance. In this issue of Immunity, Gerlach et al. (2016) describe three distinct memory CD8+ T cell subsets based upon expression of the fractalkine receptor CX3CR1. Their findings revise the paradigm of effector and central memory T cells by revealing a subset of CD8+ memory T cells defined by intermediate levels of expression of CX3CR1 that conducts tissue surveillance.
ISSN:	1074-7613 1097-4180
DOI:	10.1016/j.immuni.2016.12.005