MicroRNAs as novel targets and tools in cancer therapy

Highlights • MicroRNAs are both relevant molecular targets and therapeutic targets in cancer. • Diverse synthetic antagonists have been developed and can be used to target miRNAs in vivo. • The delivery of miRNA mimics and inhibitors to specific organs is still a therapeutic challenge. • A liposome-...

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Veröffentlicht in:	Cancer letters 2017-02, Vol.387, p.84-94
Hauptverfasser:	Abba, Mohammed L, Patil, Nitin, Leupold, Jörg Hendrik, Moniuszko, Marcin, Utikal, Jochen, Niklinski, Jacek, Allgayer, Heike
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Cancer therapies Conflicts of interest Diabetes Fibroblasts Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Hematology, Oncology and Palliative Medicine Humans Metastasis MicroRNAs MicroRNAs - genetics Neoplasms - diagnosis Neoplasms - genetics Neoplasms - therapy Oncogenes - genetics Stem cells Therapy
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container_title	Cancer letters
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creator	Abba, Mohammed L Patil, Nitin Leupold, Jörg Hendrik Moniuszko, Marcin Utikal, Jochen Niklinski, Jacek Allgayer, Heike
description	Highlights • MicroRNAs are both relevant molecular targets and therapeutic targets in cancer. • Diverse synthetic antagonists have been developed and can be used to target miRNAs in vivo. • The delivery of miRNA mimics and inhibitors to specific organs is still a therapeutic challenge. • A liposome-based miR-34 mimic (MRX34), is the first cancer-targeted microRNA drug to enter Phase I clinical trials in human patients.
doi_str_mv	10.1016/j.canlet.2016.03.043
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source	MEDLINE; Elsevier ScienceDirect Journals
subjects	Animals Cancer Cancer therapies Conflicts of interest Diabetes Fibroblasts Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Hematology, Oncology and Palliative Medicine Humans Metastasis MicroRNAs MicroRNAs - genetics Neoplasms - diagnosis Neoplasms - genetics Neoplasms - therapy Oncogenes - genetics Stem cells Therapy
title	MicroRNAs as novel targets and tools in cancer therapy
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