Lung cancer stem cells: The root of resistance

Highlights • Therapeutic resistance and tumor recurrence is common in lung cancer. • Cancer stem cells (CSCs) have the ability to self-renew and differentiate. • CSCs display robust intrinsic resistance to chemotherapy. • Targeting CSCs may enhance tumor response and prevent relapse in NSCLC patient...

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Veröffentlicht in:	Cancer letters 2016-03, Vol.372 (2), p.147-156
Hauptverfasser:	MacDonagh, Lauren, Gray, Steven G, Breen, Eamon, Cuffe, Sinead, Finn, Stephen P, O'Byrne, Kenneth J, Barr, Martin P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast cancer Cancer stem cells Cancer therapies Cell Differentiation - drug effects Cell division Cell Proliferation - drug effects Chemotherapy Clinical trials Cytotoxicity Drug Resistance, Neoplasm - genetics Drugs Hematology, Oncology and Palliative Medicine Humans Hypotheses Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Markers Medical prognosis Metastasis Molecular Targeted Therapy Mortality Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Patients Phenotype Population Resistance Side-Population Cells - drug effects Side-Population Cells - metabolism Side-Population Cells - pathology Signal Transduction - drug effects Stem cells Studies Telomerase
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Beschreibung
Zusammenfassung:	Highlights • Therapeutic resistance and tumor recurrence is common in lung cancer. • Cancer stem cells (CSCs) have the ability to self-renew and differentiate. • CSCs display robust intrinsic resistance to chemotherapy. • Targeting CSCs may enhance tumor response and prevent relapse in NSCLC patients. • Further studies are warranted in the targeting of resistant tumorigenic lung CSCs.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.01.012