Early effects of adjuvant breast cancer radiotherapy on right ventricular systolic and diastolic function
Reduced right ventricular (RV) systolic function correlates with poor prognosis in several heart diseases. The aim of this prospective single-Center study was to investigate whether conformal three-dimensional (3D) breast cancer radiotherapy impairs RV function. Forty-nine patients with early-stage...
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| Veröffentlicht in: | Anticancer research 2015-04, Vol.35 (4), p.2141-2147 |
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| creator | Tuohinen, Suvi Sirkku Skyttä, Tanja Virtanen, Vesa Luukkaala, Tiina Kellokumpu-Lehtinen, Pirkko-Liisa Raatikainen, Pekka |
| description | Reduced right ventricular (RV) systolic function correlates with poor prognosis in several heart diseases. The aim of this prospective single-Center study was to investigate whether conformal three-dimensional (3D) breast cancer radiotherapy impairs RV function.
Forty-nine patients with early-stage left-sided breast cancer underwent comprehensive two-dimensional (2D) echocardiography before and after radiotherapy. RV function was evaluated with tricuspid annular plane systolic excursion (TAPSE), pulsed tissue Doppler peak velocity at the lateral RV wall (S') and RV and venous flow analysis.
Radiotherapy reduced TAPSE from 24.5 ± 4.0 mm to 22.4 ± 3.9 mm (p |
| format | Article |
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Forty-nine patients with early-stage left-sided breast cancer underwent comprehensive two-dimensional (2D) echocardiography before and after radiotherapy. RV function was evaluated with tricuspid annular plane systolic excursion (TAPSE), pulsed tissue Doppler peak velocity at the lateral RV wall (S') and RV and venous flow analysis.
Radiotherapy reduced TAPSE from 24.5 ± 4.0 mm to 22.4 ± 3.9 mm (p<0.001), S' from 12.7 ± 3.1 m/s to 12.2 ± 2.7 m/s (p=0.11) and pulmonary flow velocity time integral (VTI) from 16.6 ± 3.1 cm to 15.9 ± 2.3 cm (p=0.07), respectively. These changes were unrelated to changes in LV function.
Modern radiotherapy reduced RV systolic function. As a readily-available and sensitive measurement, TAPSE is as a practical tool for detection of radiotherapy-induced cardiac changes.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 25862870</identifier><language>eng</language><publisher>Greece</publisher><subject>Aged ; Breast Neoplasms - drug therapy ; Breast Neoplasms - pathology ; Breast Neoplasms - radiotherapy ; Echocardiography, Doppler ; Female ; Humans ; Middle Aged ; Prognosis ; Radiation Dosage ; Radiotherapy, Adjuvant - methods ; Tricuspid Valve - pathology ; Ventricular Function, Right</subject><ispartof>Anticancer research, 2015-04, Vol.35 (4), p.2141-2147</ispartof><rights>Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25862870$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tuohinen, Suvi Sirkku</creatorcontrib><creatorcontrib>Skyttä, Tanja</creatorcontrib><creatorcontrib>Virtanen, Vesa</creatorcontrib><creatorcontrib>Luukkaala, Tiina</creatorcontrib><creatorcontrib>Kellokumpu-Lehtinen, Pirkko-Liisa</creatorcontrib><creatorcontrib>Raatikainen, Pekka</creatorcontrib><title>Early effects of adjuvant breast cancer radiotherapy on right ventricular systolic and diastolic function</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Reduced right ventricular (RV) systolic function correlates with poor prognosis in several heart diseases. The aim of this prospective single-Center study was to investigate whether conformal three-dimensional (3D) breast cancer radiotherapy impairs RV function.
Forty-nine patients with early-stage left-sided breast cancer underwent comprehensive two-dimensional (2D) echocardiography before and after radiotherapy. RV function was evaluated with tricuspid annular plane systolic excursion (TAPSE), pulsed tissue Doppler peak velocity at the lateral RV wall (S') and RV and venous flow analysis.
Radiotherapy reduced TAPSE from 24.5 ± 4.0 mm to 22.4 ± 3.9 mm (p<0.001), S' from 12.7 ± 3.1 m/s to 12.2 ± 2.7 m/s (p=0.11) and pulmonary flow velocity time integral (VTI) from 16.6 ± 3.1 cm to 15.9 ± 2.3 cm (p=0.07), respectively. These changes were unrelated to changes in LV function.
Modern radiotherapy reduced RV systolic function. As a readily-available and sensitive measurement, TAPSE is as a practical tool for detection of radiotherapy-induced cardiac changes.</description><subject>Aged</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - radiotherapy</subject><subject>Echocardiography, Doppler</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Radiation Dosage</subject><subject>Radiotherapy, Adjuvant - methods</subject><subject>Tricuspid Valve - pathology</subject><subject>Ventricular Function, Right</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1KAzEYRYMotlZfQbJ0M5DJ30yWUuoPFNzoeviSfGNTppmaZArz9grWtavLuRzu4l6QZd2YumqUYJdkybhiVcOYWpCbnPeMaW1acU0WXLWatw1bkrCBNMwU-x5dyXTsKfj9dIJYqE0IuVAH0WGiCXwYyw4THGc6RprC567QE8aSgpsGSDTPuYxDcBSipz7AmfopuhLGeEuuehgy3p1zRT6eNu_rl2r79vy6ftxWRy5lqawD78DInluOXqJujK0NorGeM6O1Fo00vW3RGAXip2sVClBcW-klcCtW5OF395jGrwlz6Q4hOxwGiDhOuatbZWTLjWD_q7rhmkml6x_1_qxO9oC-O6ZwgDR3f0-Kb-Cscm4</recordid><startdate>201504</startdate><enddate>201504</enddate><creator>Tuohinen, Suvi Sirkku</creator><creator>Skyttä, Tanja</creator><creator>Virtanen, Vesa</creator><creator>Luukkaala, Tiina</creator><creator>Kellokumpu-Lehtinen, Pirkko-Liisa</creator><creator>Raatikainen, Pekka</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>201504</creationdate><title>Early effects of adjuvant breast cancer radiotherapy on right ventricular systolic and diastolic function</title><author>Tuohinen, Suvi Sirkku ; Skyttä, Tanja ; Virtanen, Vesa ; Luukkaala, Tiina ; Kellokumpu-Lehtinen, Pirkko-Liisa ; Raatikainen, Pekka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p244t-bcadca94f2b2ed4e679b19ee9bd2096663749fb8e995a3d2085e3a526b4d4a2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - radiotherapy</topic><topic>Echocardiography, Doppler</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Radiation Dosage</topic><topic>Radiotherapy, Adjuvant - methods</topic><topic>Tricuspid Valve - pathology</topic><topic>Ventricular Function, Right</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tuohinen, Suvi Sirkku</creatorcontrib><creatorcontrib>Skyttä, Tanja</creatorcontrib><creatorcontrib>Virtanen, Vesa</creatorcontrib><creatorcontrib>Luukkaala, Tiina</creatorcontrib><creatorcontrib>Kellokumpu-Lehtinen, Pirkko-Liisa</creatorcontrib><creatorcontrib>Raatikainen, Pekka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tuohinen, Suvi Sirkku</au><au>Skyttä, Tanja</au><au>Virtanen, Vesa</au><au>Luukkaala, Tiina</au><au>Kellokumpu-Lehtinen, Pirkko-Liisa</au><au>Raatikainen, Pekka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early effects of adjuvant breast cancer radiotherapy on right ventricular systolic and diastolic function</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2015-04</date><risdate>2015</risdate><volume>35</volume><issue>4</issue><spage>2141</spage><epage>2147</epage><pages>2141-2147</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Reduced right ventricular (RV) systolic function correlates with poor prognosis in several heart diseases. The aim of this prospective single-Center study was to investigate whether conformal three-dimensional (3D) breast cancer radiotherapy impairs RV function.
Forty-nine patients with early-stage left-sided breast cancer underwent comprehensive two-dimensional (2D) echocardiography before and after radiotherapy. RV function was evaluated with tricuspid annular plane systolic excursion (TAPSE), pulsed tissue Doppler peak velocity at the lateral RV wall (S') and RV and venous flow analysis.
Radiotherapy reduced TAPSE from 24.5 ± 4.0 mm to 22.4 ± 3.9 mm (p<0.001), S' from 12.7 ± 3.1 m/s to 12.2 ± 2.7 m/s (p=0.11) and pulmonary flow velocity time integral (VTI) from 16.6 ± 3.1 cm to 15.9 ± 2.3 cm (p=0.07), respectively. These changes were unrelated to changes in LV function.
Modern radiotherapy reduced RV systolic function. As a readily-available and sensitive measurement, TAPSE is as a practical tool for detection of radiotherapy-induced cardiac changes.</abstract><cop>Greece</cop><pmid>25862870</pmid><tpages>7</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Breast Neoplasms - drug therapy Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Echocardiography, Doppler Female Humans Middle Aged Prognosis Radiation Dosage Radiotherapy, Adjuvant - methods Tricuspid Valve - pathology Ventricular Function, Right |
| title | Early effects of adjuvant breast cancer radiotherapy on right ventricular systolic and diastolic function |
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