Early effects of adjuvant breast cancer radiotherapy on right ventricular systolic and diastolic function

Reduced right ventricular (RV) systolic function correlates with poor prognosis in several heart diseases. The aim of this prospective single-Center study was to investigate whether conformal three-dimensional (3D) breast cancer radiotherapy impairs RV function. Forty-nine patients with early-stage...

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Veröffentlicht in:	Anticancer research 2015-04, Vol.35 (4), p.2141-2147
Hauptverfasser:	Tuohinen, Suvi Sirkku, Skyttä, Tanja, Virtanen, Vesa, Luukkaala, Tiina, Kellokumpu-Lehtinen, Pirkko-Liisa, Raatikainen, Pekka
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Breast Neoplasms - drug therapy Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Echocardiography, Doppler Female Humans Middle Aged Prognosis Radiation Dosage Radiotherapy, Adjuvant - methods Tricuspid Valve - pathology Ventricular Function, Right
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Zusammenfassung:	Reduced right ventricular (RV) systolic function correlates with poor prognosis in several heart diseases. The aim of this prospective single-Center study was to investigate whether conformal three-dimensional (3D) breast cancer radiotherapy impairs RV function. Forty-nine patients with early-stage left-sided breast cancer underwent comprehensive two-dimensional (2D) echocardiography before and after radiotherapy. RV function was evaluated with tricuspid annular plane systolic excursion (TAPSE), pulsed tissue Doppler peak velocity at the lateral RV wall (S') and RV and venous flow analysis. Radiotherapy reduced TAPSE from 24.5 ± 4.0 mm to 22.4 ± 3.9 mm (p
ISSN:	0250-7005 1791-7530