STAT1 as a downstream mediator of ERK signaling contributes to bone cancer pain by regulating MHC II expression in spinal microglia

Highlights • MHC II was expressed on activated microglia in the spinal cord dorsal horn of BCP rats. • STAT1 is a major mediator in modulating the expression of MHC II in microglia. • Phosphorylation of STAT1 is regulated by ERK signaling under BCP condition.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2017-02, Vol.60, p.161-173
Hauptverfasser:	Song, Zhenpeng, Xiong, Bingrui, Zheng, Hua, Manyande, Anne, Guan, Xuehai, Cao, Fei, Ren, Lifang, Zhou, Yaqun, Ye, Dawei, Tian, Yuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Bone cancer pain ERK Major histocompatibility complex class II Microglia Psychiatry STAT1
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Highlights • MHC II was expressed on activated microglia in the spinal cord dorsal horn of BCP rats. • STAT1 is a major mediator in modulating the expression of MHC II in microglia. • Phosphorylation of STAT1 is regulated by ERK signaling under BCP condition.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.10.009