Evolution of metabolic disorder in rats fed high sucrose or high fat diet: Focus on redox state and mitochondrial function

Highlights • HS diet induced mild-non-symptom-severe metabolic abnormality from 2 to 4 month. • HF diet induced early responsive-gradually severe metabolic disorder from 2 to 4 month. • Final mitochondrial dysfunction combined with ROS generation is the common pathway.

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Bibliographische Detailangaben
Veröffentlicht in:	General and comparative endocrinology 2017-02, Vol.242, p.92-100
Hauptverfasser:	Long, Zi, Zhang, Xuesi, Sun, Quangui, Liu, Ying, Liao, Nai, Wu, Hao, Wang, Xin, Hai, Chunxu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diet, High-Fat - adverse effects Dietary Sucrose - administration & dosage Dietary Sucrose - adverse effects Endocrinology & Metabolism Energy Metabolism Glucose - metabolism Glucose Intolerance - metabolism High fat diet High sucrose diet Insulin - metabolism Insulin Resistance Male Metabolic Diseases Metabolic dysfunction Mitochondria - drug effects Mitochondria - physiology Mitochondrial dysfunction Oxidation-Reduction Oxidative Stress Rats ROS generation
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Beschreibung
Zusammenfassung:	Highlights • HS diet induced mild-non-symptom-severe metabolic abnormality from 2 to 4 month. • HF diet induced early responsive-gradually severe metabolic disorder from 2 to 4 month. • Final mitochondrial dysfunction combined with ROS generation is the common pathway.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2015.10.012