Malignant transformation of human gastric epithelium cells via reactive oxygen species production and Wnt/β-catenin pathway activation following 40-week exposure to ochratoxin A

Highlights • Long-term OTA treatment can induce the malignant transformation of GES-1 cells.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2016-03, Vol.372 (1), p.36-47
Hauptverfasser:	Jia, Xin, Cui, Jinfeng, Meng, Xinxing, Xing, Lingxiao, Shen, Haitao, Wang, Juan, Liu, Jing, Wang, Yuan, Lian, Weiguang, Zhang, Xianghong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticarcinogenic Agents - pharmacology Antioxidants - pharmacology beta Catenin - metabolism Carcinogens - toxicity Cell Line Cell Movement - drug effects Cell Proliferation - drug effects Cell Transformation, Neoplastic - chemically induced Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Gastric Mucosa - drug effects Gastric Mucosa - metabolism Gastric Mucosa - pathology Hematology, Oncology and Palliative Medicine Humans Male Malignant transformation Mice, Inbred BALB C Mice, Nude Neoplasm Invasiveness Ochratoxin A Ochratoxins - toxicity Oxidative stress Oxidative Stress - drug effects Reactive Oxygen Species - metabolism Stomach Neoplasms - chemically induced Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach Neoplasms - prevention & control Time Factors Wnt Signaling Pathway - drug effects Wnt/β-catenin signaling pathway Xenograft Model Antitumor Assays Xenografts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Long-term OTA treatment can induce the malignant transformation of GES-1 cells.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2015.12.007