Increased Expression of HERPUD1 Involves in Neuronal Apoptosis after Intracerebral Hemorrhage

Highlights • Expression of HERPUD1 was obviously increased around the hematoma in rat ICH model. • The expression of apoptosis markers including cytochrome c (cyt c ) and active caspase-3 increased accompanied to HERPUD1 in vivo. • HERPUD1 silence brought about up-regulation of cyt c and active casp...

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Veröffentlicht in:	Brain research bulletin 2017-01, Vol.128, p.40-47
Hauptverfasser:	Ding, Wensen, Chen, Rongrong, Wu, Chunshuai, Chen, Weihai, Zhang, Hongtian, Fan, Xingjuan, Wang, Hongmei, Ji, Yuteng, Xie, Lili, Ning, Xiaojin, Shen, Lihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - physiology Apoptosis Regulatory Proteins - metabolism Blotting, Western Caspase 3 - metabolism Cell Line, Tumor Cerebral Hemorrhage - metabolism Cerebral Hemorrhage - pathology Cytochromes c - metabolism Disease Models, Animal HERPUD1 Humans Immunohistochemistry Intracerebral hemorrhage Male Membrane Proteins - metabolism Motor Activity - physiology Neurology Neuron Neurons - metabolism Neurons - pathology Neuroprotection - physiology Rats, Sprague-Dawley
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Zusammenfassung:	Highlights • Expression of HERPUD1 was obviously increased around the hematoma in rat ICH model. • The expression of apoptosis markers including cytochrome c (cyt c ) and active caspase-3 increased accompanied to HERPUD1 in vivo. • HERPUD1 silence brought about up-regulation of cyt c and active caspase-3 coupled with increased cell apoptosis in vitro model. • HERPUD1 might play a protective role in ICH-induced neuronal apoptosis in rat models. • ER stress might play a part in the complicated and various mechanism of ICH.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2016.11.006